Prognostic Impact of Lymphatic Invasion in Patients with High-Risk Prostate Cancer after Robot-Assisted Radical Prostatectomy and Extended Lymph Node Dissection: A Single-Institution Prospective Cohort Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
3. Results
3.1. Patient Demographics and Histopathological Findings of Resected Specimens
3.2. BCR Rates
3.3. Predictive Value of Lymphatic Invasion for BCR
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age, years | 69 (66–72) 1 |
BMI, kg/m2 | 24.1 (22.0–26.2) 1 |
Smoking history, n (%) | 120 (66) |
PSA, ng/mL | 10.9 (7.5–17.1) 1 |
PSA density | 0.43 (0.26–0.67)1 |
Biopsy Gleason-grade group, n (%) | |
1 | 4 (2) |
2 | 10 (6) |
3 | 17 (9) |
4 | 110 (60) |
5 | 42 (23) |
Clinical T stage, n (%) | |
T1c | 16 (9) |
T2 | 125 (68) |
T3 | 42 (23) |
ly0 Group (n = 136) | ly1 Group (n = 47) | p Value | |
---|---|---|---|
Age, years 1 | 69 (65–72) | 69 (66–72) | 0.94 |
PSA, mg/dL 1 | 10.3 (7.0–17.0) | 11.9 (8.6–17.6) | 0.22 |
PSA density 1 | 0.42 (0.25–0.66) | 0.47 (0.30–0.74) | 0.28 |
Gleason-grade group, n (%) | <0.01 | ||
2 | 38 (28) | 6 (13) | |
3 | 59 (44) | 17 (36) | |
4 | 12 (9) | 5 (11) | |
5 | 26 (19) | 19 (40) | |
Pathological T stage, n (%) | <0.01 | ||
pT2 | 74 (54) | 12 (26) | |
pT3a | 49 (36) | 16 (34) | |
pT3b | 13 (10) | 19 (40) | |
EPE1, n (%) | 58 (43) | 31 (66) | <0.01 |
sv1, n (%) | 13 (10) | 19 (40) | <0.01 |
v1, n (%) | 3 (2) | 8 (17) | <0.01 |
RM1, n (%) | 31 (23) | 20 (43) | <0.01 |
pN1, n (%) | 5 (4) | 12 (26) | <0.01 |
Univariable Analyses | Multivariable Analyses | ||||||||
---|---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | ||||||||
HR | 95% CI | p Value | HR | 95% CI | p Value | HR | 95% CI | p Value | |
Age, years | 0.98 | 0.93–1.03 | 0.41 | ||||||
PSA, ng/mL | 1.02 | 0.98–1.05 | 0.18 | ||||||
PSA density | 1.22 | 0.57–2.36 | 0.57 | ||||||
Gleason-grade groups 4–5 (vs. 2–3) | 2.48 | 1.40–4.39 | <0.01 | 1.70 | 0.90–3.18 | 0.09 | 1.81 | 0.97–3.38 | 0.06 |
pT3 (vs. pT2) | 3.13 | 1.62–6.02 | <0.01 | 1.95 | 0.96–3.96 | 0.06 | 1.94 | 0.96–3.89 | 0.06 |
v1 (vs. v0) | 5.57 | 2.67–11.61 | <0.01 | 2.73 | 1.19–6.24 | 0.01 | 2.58 | 1.13–5.84 | 0.02 |
RM1 (vs. RM0) | 2.17 | 1.22–3.86 | <0.01 | 1.92 | 1.06–3.48 | 0.03 | 1.70 | 0.93–3.10 | 0.08 |
pN1 (vs. pN0) | 6.34 | 3.24–12.36 | <0.01 | 2.73 | 1.29–5.75 | <0.01 | |||
ly1 (vs. ly0) | 4.11 | 2.67–11.61 | <0.01 | 2.33 | 1.22–4.42 | 0.01 |
HR | 95% CI | p Value | |
---|---|---|---|
Gleason-grade groups 4–5 (vs. 2–3) | 2.03 | 0.99–4.11 | 0.05 |
pT3 (vs. pT2) | 1.75 | 0.82–3.67 | 0.14 |
RM1 (vs. RM0) | 1.93 | 0.95–3.91 | 0.06 |
v1 (vs. v0) | 4.10 | 1.50–11.19 | <0.01 |
ly1 (vs. ly0) | 2.59 | 1.25–5.32 | 0.01 |
Lymph Node Metastasis, n | ||||
---|---|---|---|---|
pN0 | pN1 | Total | ||
Micro-lymphatic invasion, n | ly0 | 131 | 5 | 136 |
ly1 | 35 | 12 | 47 | |
Total | 166 | 17 | 183 |
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Yamashita, S.; Muraoka, S.; Wakamiya, T.; Kikkawa, K.; Kohjimoto, Y.; Hara, I. Prognostic Impact of Lymphatic Invasion in Patients with High-Risk Prostate Cancer after Robot-Assisted Radical Prostatectomy and Extended Lymph Node Dissection: A Single-Institution Prospective Cohort Study. Cancers 2022, 14, 3466. https://doi.org/10.3390/cancers14143466
Yamashita S, Muraoka S, Wakamiya T, Kikkawa K, Kohjimoto Y, Hara I. Prognostic Impact of Lymphatic Invasion in Patients with High-Risk Prostate Cancer after Robot-Assisted Radical Prostatectomy and Extended Lymph Node Dissection: A Single-Institution Prospective Cohort Study. Cancers. 2022; 14(14):3466. https://doi.org/10.3390/cancers14143466
Chicago/Turabian StyleYamashita, Shimpei, Satoshi Muraoka, Takahito Wakamiya, Kazuro Kikkawa, Yasuo Kohjimoto, and Isao Hara. 2022. "Prognostic Impact of Lymphatic Invasion in Patients with High-Risk Prostate Cancer after Robot-Assisted Radical Prostatectomy and Extended Lymph Node Dissection: A Single-Institution Prospective Cohort Study" Cancers 14, no. 14: 3466. https://doi.org/10.3390/cancers14143466