The Potential of Novel Lipid Agents for the Treatment of Chemotherapy-Resistant Human Epithelial Ovarian Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. GAELs: How Did We Get Here?
3. GAEL Structure–Activity Relationship
4. GAEL Cell-Killing Activity against Epithelial Ovarian Cancer
5. GAEL Mechanism of Action
6. Conclusions: Utility of GAELs and Methuosis-Inducing Compounds for EOC Treatment
Author Contributions
Funding
Conflicts of Interest
References
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Group | Group Name | Dose Schedule/Termination | Mice with Solid Tumors | Ascites (%) |
---|---|---|---|---|
2 * | Vehicle—2 | Q4Dx8 Termination: day 74 *** | 100% (12/12) @ | 92% (11/12) |
4 * | L-Rham—low 2 | Q4Dx8 Termination: day 74 *** | 33% (2/6) | 0% (0/6) |
5 ** | L-Rham—high | Q4Dx8 Termination: day 74 *** | 100% (6/6) | 0% (0/6) |
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Nachtigal, M.W.; Altman, A.D.; Arora, R.; Schweizer, F.; Arthur, G. The Potential of Novel Lipid Agents for the Treatment of Chemotherapy-Resistant Human Epithelial Ovarian Cancer. Cancers 2022, 14, 3318. https://doi.org/10.3390/cancers14143318
Nachtigal MW, Altman AD, Arora R, Schweizer F, Arthur G. The Potential of Novel Lipid Agents for the Treatment of Chemotherapy-Resistant Human Epithelial Ovarian Cancer. Cancers. 2022; 14(14):3318. https://doi.org/10.3390/cancers14143318
Chicago/Turabian StyleNachtigal, Mark W., Alon D. Altman, Rajat Arora, Frank Schweizer, and Gilbert Arthur. 2022. "The Potential of Novel Lipid Agents for the Treatment of Chemotherapy-Resistant Human Epithelial Ovarian Cancer" Cancers 14, no. 14: 3318. https://doi.org/10.3390/cancers14143318