Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Procedures
2.3. Measures
2.3.1. Insomnia Severity Index (ISI)
2.3.2. Daytime Fatigue
2.3.3. Risk Factors
2.4. Statistical Analyses
3. Results
3.1. Sample Characteristics
3.2. Prevalence Rates of Insomnia and Daytime Fatigue
3.3. Clinical Severity Ranges of Insomnia in the Total and Subgroups
3.4. Risk Factors of Insomnia and Daytime Fatigue Groups
4. Discussion
Strengths and Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total Group (n = 565) | Insomnia-Daytime Fatigue Subgroups | ||||
---|---|---|---|---|---|
Insomnia and Daytime Fatigue (n = 104) | Insomnia Only (n = 75) | Daytime Fatigue Only (n = 37) | No Symptoms (n = 349) | ||
Age at study invitation (y), mean (SD) Age group, % Adolescents (12–17y) Young adult (18–26y) | 17.0 (2.9) 57.3 42.8 | 17.8 (2.7) 40.4 59.6 | 16.6 (2.0) 68.0 32.0 | 18.5 (2.7) 35.1 64.9 | 16.7 (2.9) 62.2 37.8 |
Sex, % Female | 49.6 | 66.3 | 57.3 | 78.4 | 39.8 |
Current educational level, % Low Middle High | 23.9 56.6 18.2 | 27.9 51.9 17.3 | 25.3 64.0 10.7 | 24.3 40.5 32.4 | 22.3 58.2 18.6 |
Country of birth, % The Netherlands Other | 95.2 3.4 | 90.4 7.7 | 94.7 5.3 | 94.6 2.7 | 96.8 1.7 |
Age at diagnosis (y), mean (SD) | 12.8 (3.2) | 13.5 (3.3) | 13.0 (2.9) | 13.9 (2.6) | 12.5 (3.2) |
Time since diagnosis in years, mean (SD) | 4.0 (2.4) | 4.1 (2.4) | 3.5 (1.9) | 4.3 (2.5) | 4.0 (2.4) |
Diagnosis groups, % Hemato-oncology Neuro-oncology Solid | 44.1 23.7 32.2 | 45.2 28.8 26.0 | 49.3 13.3 37.3 | 43.2 21.6 35.1 | 42.7 24.6 32.7 |
Time since end of treatment in years, mean (SD) | 3.2 (2.2) | 3.3 (2.1) | 2.7 (1.8) | 3.2 (2.4) | 3.3 (2.3) |
Type of oncologic treatment, % No treatment Chemotherapy Radiation Surgery SCT Mixed/Other | 1.4 73.1 25.5 54.7 6.2 4.8 | 0.9 67.3 24.0 63.5 9.6 6.7 | - 73.3 21.3 54.7 6.7 6.7 | 2.7 73.0 24.3 54.1 5.4 - | 2.0 74.8 26.9 52.1 5.2 4.0 |
Comorbid health problems, % Yes | 17.9 | 31.7 | 22.7 | 32.4 | 11.2 |
Sleeping accompanied, % Yes | 7.4 | 15.4 | 6.7 | 8.3 | 5.2 |
Sleep behaviors, mean (SD) Needing someone else to fall asleep Bedtime routine Trying to fall asleep every night at the same time Waking up every morning at the same time Bedtime technology TV Games Phone/computer | 1.18 (.67) 3.43 (1.44) 3.35 (1.20) 3.43 (1.12) 3.60 (1.20) 2.10 (1.28) 3.83 (1.31) | 1.52 (1.08) 3.75 (1.15) 3.64 (1.04) 3.13 (1.14) 3.66 (1.03) 2.07 (1.22) 4.04 (1.07) | 1.25 (.81) 3.43 (1.31) 3.43 (1.27) 3.33 (1.08) 3.65 (1.07) 2.25 (1.35) 3.69 (1.38) | 1.05 (.23) 3.59 (1.46) 3.46 (1.10) 3.24 (1.09) 3.46 (1.32) 1.68 (1.18) 4.27 (1.05) | 1.08 (.44) 3.32 (1.53) 3.24 (1.23) 3.57 (1.11) 3.58 (1.26) 2.13 (1.29) 3.74 (1.36) |
Total Group (n = 565) | Insomnia-Daytime Fatigue Subgroups | ||||
---|---|---|---|---|---|
Insomnia and Daytime Fatigue (n = 104) | Insomnia Only (n = 75) | Daytime Fatigue Only (n = 37) | No Symptoms (n = 349) | ||
Insomnia categories (n, %): No clinically significant insomnia (ISI: 0–7) Subthreshold insomnia (ISI: 8–14) Clinical insomnia (moderate severity, ISI: 15–21) Clinical insomnia (severe, ISI: 22–28) | 386 (68.3) 115 (20.4) 56 (9.9) 8 (1.4) | - 49 (47.1) 47 (45.1) 8 (7.7) | - 66 (88.0) 9 (12.0) - | 37 (100.0) - - - | 349 (100.0) - - - |
ISI score, mean (SD) | 6.15 (5.84) | 14.89 (4.72) | 11.41 (2.96) | 4.59 (1.69) | 2.58 (2.18) |
Reference: No Symptoms (n = 349) | Insomnia and Daytime Fatigue (n = 104) | Insomnia Only (n = 75) | Daytime Fatigue Only (n = 37) |
---|---|---|---|
Female | 3.08 (1.75–5.41) *** | 2.41 (1.34–4.35) ** | 6.38 (2.44–16.70) *** |
Age group: young adults (ref: adolescents) | 3.11 (1.75–5.54) *** | 1.09 (0.55–2.14) | 3.95 (1.58–9.90) ** |
High educational level (ref: low/middle) | 0.36 (0.17–0.76) ** | 0.58 (0.22–1.50) | 0.95 (0.37–2.47) |
Having a comorbid health condition | 4.53 (2.47–8.31) *** | 3.00 (1.50–5.98) ** | 4.32 (1.79–10.44) ** |
Time since end of treatment (in years) | 0.93 (0.83–1.05) | 0.86 (0.75–0.99) * | 0.85 (0.70–1.02) |
Needing someone else to fall asleep | 1.79 (1.25–2.56) ** | 1.56 (1.04–2.33) * | 0.63 (0.20–1.97) |
Trying to fall asleep every night at the same time | 1.40 (1.10–1.77)** | 1.19 (0.93–1.51) | 1.10 (0.77–1.56) |
Waking up every morning at the same time | 0.65 (0.51–0.82) *** | 0.77 (0.60–1.00) * | 0.72 (0.51–1.03) |
Bedtime technology use-gaming | 1.17 (0.94–1.45) | 1.27 (1.03–1.59) * | 0.98 (0.67–1.44) |
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Peersmann, S.H.M.; Grootenhuis, M.A.; van Straten, A.; Tissing, W.J.E.; Abbink, F.; de Vries, A.C.H.; Loonen, J.; van der Pal, H.J.H.; Kaspers, G.J.L.; van Litsenburg, R.R.L. Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors. Cancers 2022, 14, 3316. https://doi.org/10.3390/cancers14143316
Peersmann SHM, Grootenhuis MA, van Straten A, Tissing WJE, Abbink F, de Vries ACH, Loonen J, van der Pal HJH, Kaspers GJL, van Litsenburg RRL. Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors. Cancers. 2022; 14(14):3316. https://doi.org/10.3390/cancers14143316
Chicago/Turabian StylePeersmann, Shosha H. M., Martha A. Grootenhuis, Annemieke van Straten, Wim J. E. Tissing, Floor Abbink, Andrica C. H. de Vries, Jacqueline Loonen, Helena J. H. van der Pal, Gertjan J. L. Kaspers, and Raphaële R. L. van Litsenburg. 2022. "Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors" Cancers 14, no. 14: 3316. https://doi.org/10.3390/cancers14143316
APA StylePeersmann, S. H. M., Grootenhuis, M. A., van Straten, A., Tissing, W. J. E., Abbink, F., de Vries, A. C. H., Loonen, J., van der Pal, H. J. H., Kaspers, G. J. L., & van Litsenburg, R. R. L. (2022). Insomnia Symptoms and Daytime Fatigue Co-Occurrence in Adolescent and Young Adult Childhood Cancer Patients in Follow-Up after Treatment: Prevalence and Associated Risk Factors. Cancers, 14(14), 3316. https://doi.org/10.3390/cancers14143316