Scales of Cancer Evolution: Selfish Genome or Cooperating Cells?
Abstract
Simple Summary
Abstract
1. Introduction
2. Biological Background
2.1. Intratumour Heterogeneity
2.2. Phenotypic Plasticity
2.3. Cancer Cell State Dynamics
3. Evolutionary Aspects
3.1. Cancer Relevant Scales
3.2. Cancer Genome’s Fitness
4. Cancer Clone as Cooperating Group
4.1. Exploration vs. Exploitation Dilemma
4.2. Is Cancer Hedging Its Bets?
5. Conclusions
Funding
Conflicts of Interest
References
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Brutovský, B. Scales of Cancer Evolution: Selfish Genome or Cooperating Cells? Cancers 2022, 14, 3253. https://doi.org/10.3390/cancers14133253
Brutovský B. Scales of Cancer Evolution: Selfish Genome or Cooperating Cells? Cancers. 2022; 14(13):3253. https://doi.org/10.3390/cancers14133253
Chicago/Turabian StyleBrutovský, Branislav. 2022. "Scales of Cancer Evolution: Selfish Genome or Cooperating Cells?" Cancers 14, no. 13: 3253. https://doi.org/10.3390/cancers14133253
APA StyleBrutovský, B. (2022). Scales of Cancer Evolution: Selfish Genome or Cooperating Cells? Cancers, 14(13), 3253. https://doi.org/10.3390/cancers14133253