Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma
1
Laboratory of Nervous System Diseases and Therapy, GIGA Neuroscience, GIGA Institute, University of Liège, 4000 Liege, Belgium
2
Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health, 1445 Strassen, Luxembourg
3
Faculty of Science, Technology and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg
4
Neurology Department, University Hospital, University of Liège, 4000 Liege, Belgium
5
Neurosurgery Department, University Hospital, University of Liège, 4000 Liege, Belgium
6
Tumor Immunotherapy and Microenvironment, Department of Oncology, Luxembourg Institute of Health, 1445 Strassen, Luxembourg
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Bernhard Moser
Cancers 2022, 14(1), 130; https://doi.org/10.3390/cancers14010130
Received: 23 November 2021
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Revised: 23 December 2021
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Accepted: 24 December 2021
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Published: 28 December 2021
(This article belongs to the Special Issue Emerging Roles of Chemokines in Cancer Immunotherapy)
Simple Summary
Chemokines and their receptors have been pointed out as key actors in a variety of human cancers, playing pivotal roles in multiples processes and pathways. The present study aims at deciphering the functions of several chemokine receptors in gliomas, starting from publicly available patient-derived transcriptomic data with support from the current literature in the field, and sheds light on the clinical relevance of chemokine receptors in targeted therapeutic approaches for glioma patients.
Gliomas are severe brain malignancies, with glioblastoma (GBM) being the most aggressive one. Despite continuous efforts for improvement of existing therapies, overall survival remains poor. Over the last years, the implication of chemokines and their receptors in GBM development and progression has become more evident. Recently, large amounts of clinical data have been made available, prompting us to investigate chemokine receptors in GBM from a still-unexplored patient-oriented perspective. This study aims to highlight and discuss the involvement of chemokine receptors—CCR1, CCR5, CCR6, CCR10, CX3CR1, CXCR2, CXCR4, ACKR1, ACKR2, and ACKR3—most abundantly expressed in glioma patients based on the analysis of publicly available clinical datasets. Given the strong intratumoral heterogeneity characterizing gliomas and especially GBM, receptor expression was investigated by glioma molecular groups, by brain region distribution, emphasizing tissue-specific receptor functions, and by cell type enrichment. Our study constitutes a clinically relevant and patient-oriented guide that recapitulates the expression profile and the complex roles of chemokine receptors within the highly diversified glioma landscape. Additionally, it strengthens the importance of patient-derived material for development and precise amelioration of chemokine receptor-targeting therapies.
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Keywords:
glioma; chemokine receptor; patient-derived transcriptomic data; malignant processes; tumor microenvironment
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MDPI and ACS Style
Isci, D.; D’Uonnolo, G.; Wantz, M.; Rogister, B.; Lombard, A.; Chevigné, A.; Szpakowska, M.; Neirinckx, V. Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma. Cancers 2022, 14, 130. https://doi.org/10.3390/cancers14010130
AMA Style
Isci D, D’Uonnolo G, Wantz M, Rogister B, Lombard A, Chevigné A, Szpakowska M, Neirinckx V. Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma. Cancers. 2022; 14(1):130. https://doi.org/10.3390/cancers14010130
Chicago/Turabian StyleIsci, Damla, Giulia D’Uonnolo, May Wantz, Bernard Rogister, Arnaud Lombard, Andy Chevigné, Martyna Szpakowska, and Virginie Neirinckx. 2022. "Patient-Oriented Perspective on Chemokine Receptor Expression and Function in Glioma" Cancers 14, no. 1: 130. https://doi.org/10.3390/cancers14010130
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