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Review

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

1
Department of Chemistry, Biology, Pharmacy and Environmental Science, University of Messina, 98122 Messina, Italy
2
IOM Ricerca, Viagrande, 95029 Catania, Italy
3
Department of Drug Science and Health, University of Catania, 95125 Catania, Italy
*
Authors to whom correspondence should be addressed.
Two authors contributed equally to this work.
Academic Editor: Clare Hoskins
Cancers 2021, 13(9), 1991; https://doi.org/10.3390/cancers13091991
Received: 21 March 2021 / Revised: 17 April 2021 / Accepted: 19 April 2021 / Published: 21 April 2021
Diagnostic approaches and chemotherapeutic delivery based on nanotechnologies, such as nanoparticles (NPs), could be promising candidates for the new era of cancer research. Recently great attention has been received by carbon-based nanomaterials such as Carbon Dots (CDs), due their variegated physical-chemical properties that makes these systems appealing for multiple use from bioimaging, biosensing, nano-carriers for drug delivery systems to innovative therapeutic agents in photodynamic (PDT) and photothermal therapy (PTT). In this review, we report the last evidence on the application and prospects of CDs as useful nano theranostics tools for cancer diagnosis and therapy.
Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy. View Full-Text
Keywords: carbon dots; cancer diagnosis cancer therapy; bioimaging; drug delivery; photodynamic therapy; photothermal therapy carbon dots; cancer diagnosis cancer therapy; bioimaging; drug delivery; photodynamic therapy; photothermal therapy
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MDPI and ACS Style

Nocito, G.; Calabrese, G.; Forte, S.; Petralia, S.; Puglisi, C.; Campolo, M.; Esposito, E.; Conoci, S. Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy. Cancers 2021, 13, 1991. https://doi.org/10.3390/cancers13091991

AMA Style

Nocito G, Calabrese G, Forte S, Petralia S, Puglisi C, Campolo M, Esposito E, Conoci S. Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy. Cancers. 2021; 13(9):1991. https://doi.org/10.3390/cancers13091991

Chicago/Turabian Style

Nocito, Giuseppe, Giovanna Calabrese, Stefano Forte, Salvatore Petralia, Caterina Puglisi, Michela Campolo, Emanuela Esposito, and Sabrina Conoci. 2021. "Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy" Cancers 13, no. 9: 1991. https://doi.org/10.3390/cancers13091991

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