Feasibility of Non-Exposure Simple Suturing Endoscopic Full-Thickness Resection in Comparison with Laparoscopic Endoscopic Cooperative Surgery for Gastric Subepithelial Tumors: Results of Two Independent Prospective Trials
by
, ,
Bang Wool Eom
, 
Chan Gyoo Kim
*,
Myeong-Cherl Kook
,
Hong Man Yoon
,
Keun Won Ryu
,
Young-Woo Kim
,
Ji Yoon Rho
,
Young-Il Kim
,
Jong Yeul Lee
and
Il Ju Choi
Center for Gastric Cancer, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea
*
Author to whom correspondence should be addressed.
Cancers 2021, 13(8), 1858; https://doi.org/10.3390/cancers13081858
Submission received: 16 March 2021
/
Revised: 30 March 2021
/
Accepted: 7 April 2021
/
Published: 13 April 2021
(This article belongs to the Special Issue New Technologies and Advancements in Gastro-Esophageal Cancer Surgery)
Simple Summary
Nonexposure simple suturing endoscopic full-thickness resection (NESS-EFTR) is a recently developed method to prevent the exposure of tumor cells, and we performed a small prospective trial of NESS-EFTR for gastric subepithelial tumors (SETs). In this study, we compared the results of NESS-EFTR trial with those of another small prospective trial of laparoscopic and endoscopic cooperative surgery which was performed in different time period. The results of this study show the feasibility of NESS-EFTR for gastric SETs and provide evidence for the clinical application of the NESS-EFTR procedure.
Abstract
Recently, nonexposure simple suturing endoscopic full-thickness resection (NESS-EFTR) method was developed to avoid tumor exposure to the peritoneal cavity. The aim of this study is to compare the short-term outcomes of the NESS-EFTR method with those of laparoscopic and endoscopic cooperative surgery (LECS) for gastric subepithelial tumors (SETs). A prospective single-center trial of LECS for gastric SETs was performed from March 2012 to October 2013 with a separate prospective trial of NESS-EFTR performed from August 2015 to June 2017, enrolling 15 patients each. Among the 30 enrolled patients, 14 who underwent LECS and 11 who underwent NESS-EFTR were finally included in the analysis. The rate of complete resection and successful closure was 100% in both groups. The operating time was longer for NESS-EFTR group than for LECS (110 vs. 189 min; p < 0.0001). There were no postoperative complications except one case of transient fever in the NESS-EFTR group. One patient in the LECS group had peritoneal seeding of gastrointestinal stromal tumor at 17 months postoperatively, and there was no other recurrence. Although NESS-EFTR had long operating and procedure times, it was feasible for patients with gastric SETs requiring a nonexposure technique.
