Meningiomas and Cognitive Impairment after Treatment: A Systematic and Narrative Review
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Search Strategy and Study Selection
2.2. Risk of Bias and Quality of Study
2.3. Data Collection
2.4. Statistical Analysis
3. Results
3.1. Demographic Results
3.2. Definition of Cognition
3.3. Dimensions of Cognition and Respective Assessment Tools
3.4. Outcome: Consequences of Therapy
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study Design | Retrospective: 9 |
---|---|
Prospective: 13 | |
Number of patients | Total: 1572 (range: 9–261 per study) |
Mean: 71.5 per study | |
Age | Mean: 58.4 y |
Range: 23–87 y | |
Gender | Not stated: 25/1′572 (1.6%) |
Female: 1′084/1′572 (68.9%) | |
Male: 463/1′572 (29.5%) | |
Localization | Not stated: 395/1′572 (25.1%) |
Left hemisphere: 495/1′572 (31.5%) | |
Right hemisphere: 520/1′572 (33.1%) | |
Bilateral: 162/1′572 (10.3%) | |
Frontal lobe: 403/1′572 (25.6%) | |
Mean education | Not stated: 588/1′572 (37.4%) |
Mean in years: 10.3 ±2.9 | |
Mean in level: 4.6 * | |
Assessment measures/tools | Central Nervous System Vital Signs tests (10/22 studies) |
HVLT-R, EORTC, QLQ-30, and QLQ-BN20 (3/22 studies) | |
Raven Matrices, Objects and Verbs naming, ideomotor apraxia, Token Test (2/22 studies) | |
Other neuropsychological test (7/22 studies) | |
Dimension of cognition tested | Verbal, working and visual memory (19/22 studies) |
Complex attention and orientation (18/22 studies) | |
Executive functioning (17/22 studies) | |
Language and verbal fluency (11/22 studies) | |
Cognitive flexibility (11/22 studies) | |
Neuropsychological outcome Comparison prior to and after treatment | Worsening of verbal, working and visual memory (9/22 studies) |
Worsening of complex attention and orientation (1/22 studies) | |
Worsening of executive functioning (3/22 studies) | |
Worsening of language and verbal fluency (2/22 studies) | |
Worsening of cognitive flexibility (4/22 studies) | |
Worsening in all neurocognitive domains (1/22 studies) | |
Improvement in verbal, working and visual memory (3/22 studies) | |
Improvement of complex attention and orientation (3/22 studies) | |
Improvement of executive functioning (2/22 studies) | |
Improvement of cognitive flexibility (1/22 studies) | |
Comparison with healthy population | Worse verbal, working and visual memory (2/22 studies) |
Worse complex attention and orientation (1/22 studies) | |
Worse executive functioning (1/22 studies) | |
Worse language and verbal fluency (2/22 studies) | |
Worse cognitive flexibility (4/22 studies) | |
Follow-up (years ± SD) | Not stated: 4/22 studies (18.2%) |
Mean: 0.86 ± 0.3 years |
Author, Year, Design | Sample Size (n) | Gender | Mean Age (y ± SD, Range) | Mean Education (y ± SD or Level) | Location | Assessment Measurement Tools | Cognition Dimensions Tested | Difference Between Pre- and Post-Op or Against Control Group | Follow-Up (y) |
---|---|---|---|---|---|---|---|---|---|
Van Lonkhuizen, 2019, prospective | 242 | 168 F & 74 M | 57.2 (23–82) | 5th level | 101 Left and 113 Right; 142 Frontal and 100 Non-frontal | Central Nervous System Vital Signs tests | Verbal and visual memory, reaction time, complex attention, and cognitive flexibility |
| 1 |
Rijnen, 2019, prospective | 261 | 189 F & 72 M | 57.8 ± 11.7 (23–82) | 14.0 ± 3.7 | 106 Left, 124 Right and 31 Bilateral; 154 Frontal and 107 Non-frontal | Central Nervous System Vital Signs tests | Verbal and visual memory, reaction time, complex attention and cognitive flexibility |
| 1 |
Pranckevičienė, 2019, prospective | 93 | 68 F & 25 M | 63.8 +/- 10.7 | n.a | 36 Left, 37 Right, and 20 Bilateral | HVLT-R, EORTC, QLQ-30 and QLQ-BN20 | Verbal, working and visual memory and complex attention |
| n.a |
van der Vossen, 2014, retrospective | 136 | 106 F & 30 M | 59.1 ± 12.7 | n.a | 66 Convexity and 70 Non-convexity | CFQ and HADS | Cognitive flexibility, anxiety, and depression |
| 3.0 ± 0.9 |
Krupp, 2009, retrospective | 91 | 60 F & 31 M | 56 ± 10 (31–75) | n.a | 48 Left and 43 Right; 40 Frontal and 51 Non-frontal | Others | Language and cognitive flexibility |
| 1.25 ± 0.3 |
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Gondar, R.; Patet, G.; Schaller, K.; Meling, T.R. Meningiomas and Cognitive Impairment after Treatment: A Systematic and Narrative Review. Cancers 2021, 13, 1846. https://doi.org/10.3390/cancers13081846
Gondar R, Patet G, Schaller K, Meling TR. Meningiomas and Cognitive Impairment after Treatment: A Systematic and Narrative Review. Cancers. 2021; 13(8):1846. https://doi.org/10.3390/cancers13081846
Chicago/Turabian StyleGondar, Renato, Gildas Patet, Karl Schaller, and Torstein R. Meling. 2021. "Meningiomas and Cognitive Impairment after Treatment: A Systematic and Narrative Review" Cancers 13, no. 8: 1846. https://doi.org/10.3390/cancers13081846