Malignant Pleural Mesothelioma Interactome with 364 Novel Protein-Protein Interactions
Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560012, India
Exposure Assessment Branch, National Institute of Occupational Safety and Health, Center for Disease Control, Morgantown, WV 26506, USA
Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15206, USA
Intelligent Systems Program, School of Computing and Information, University of Pittsburgh, Pittsburgh, PA 15213, USA
Author to whom correspondence should be addressed.
Academic Editors: Daniel L. Pouliquen and Joanna Kopecka
Received: 28 February 2021 / Revised: 19 March 2021 / Accepted: 22 March 2021 / Published: 1 April 2021
Internal organs like the heart and lungs, and body cavities like the thoracic and abdominal cavities, are covered by a thin, slippery layer called the mesothelium. Malignant pleural mesothelioma (MPM) is an aggressive cancer of the lining of the lung, where genetics and asbestos exposure play a role. It is not diagnosable until it becomes invasive, offering only a short survival time to the patient. To help understand the role of the genes that relate to this disease most of which are poorly understood, we constructed the ‘MPM interactome’, including in it the protein-protein interactions that we predicted computationally and those that are previously known in the literature. Five novel protein-protein interactions (PPIs) were tested and validated experimentally. 85.65% of the interactome is supported by genetic variant, transcriptomic, and proteomic evidence. Comparative transcriptome analysis revealed 5 repurposable drugs targeting the interactome proteins. We make the interactome available on a freely accessible web application, Wiki-MPM.