Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia
Abstract
:Simple Summary
Abstract
1. Introduction
2. Genetics of Chromatin-Spliceosome Acute Myeloid Leukemia (CS-AML)
2.1. Genetic Classification of AML
2.2. Definition of CS-AML
3. Driver Genes Mutated in CS-AML
3.1. Splicing Factors (SF)
3.2. Cohesin Complex
3.3. Transcription Factors
3.4. Chromatin Modifiers
4. Clinical Features of CS-AML
5. Conclusions and Future Perspectives
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Driver Mutations | Pathway/Functions | Approximate Frequency (%) | ||
---|---|---|---|---|
de novo AML | sAML | MDS | ||
SRSF2 | Spliceosome | 2–7 | 12–20 * | 12–17 † |
SF3B1 | Spliceosome | 2–10 | 7–11 * | 13–33 † |
U2AF1 | Spliceosome | 1–4 | 11–16 * | 5–11 † |
ZRSR2 | Spliceosome | 0–1 | 3–8 * | 3–8 † |
STAG2 | Cohesin | 2–7 | 10–14 * | 3–8 † |
RUNX1 | Transcription factor | 5–20 | 20–31 * | 6–14 |
EZH2 | Chromatin modification | 2–4 | 5–9 * | 4–15 † |
BCOR | Chromatin modification | 2–3 | 7–8 * | 2–6 † |
ASXL1 | Chromatin modification | 5–15 | 19–32 * | 10–23 † |
MLL-PTD | Chromatin modification | 5–8 | 14 | 4–5 |
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Ochi, Y.; Ogawa, S. Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia. Cancers 2021, 13, 1232. https://doi.org/10.3390/cancers13061232
Ochi Y, Ogawa S. Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia. Cancers. 2021; 13(6):1232. https://doi.org/10.3390/cancers13061232
Chicago/Turabian StyleOchi, Yotaro, and Seishi Ogawa. 2021. "Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia" Cancers 13, no. 6: 1232. https://doi.org/10.3390/cancers13061232
APA StyleOchi, Y., & Ogawa, S. (2021). Chromatin-Spliceosome Mutations in Acute Myeloid Leukemia. Cancers, 13(6), 1232. https://doi.org/10.3390/cancers13061232