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Article

Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial

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Freemasons Centre for Male Health & Wellbeing, School of Medicine, University of Adelaide, Adelaide 5001, Australia
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Exercise Medicine Research Institute, Edith Cowan University, Joondalup 6027, Australia
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Wolfson Palliative Care Research Centre, Institute of Clinical and Applied Health Research, Hull York Medical School, University of Hull, Hull HU6 7RX, UK
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Alliance for Research in Exercise, Nutrition and Activity, Allied Health and Human Performance, University of South Australia, Adelaide 5001, Australia
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Physical Activity Research Group, Appleton Institute, Central Queensland University, North Rockhampton 4702, Australia
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School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane 4067, Australia
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College of Medicine and Public Health, Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park 5042, Australia
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Faculty of Health Sciences, Australian Catholic University, Brisbane 4041, Australia
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Department of Surgery, School of Medicine, University of Adelaide, Adelaide 5001, Australia
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Melbourne Centre for Behaviour Change, Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne 3010, Australia
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Melbourne School of Health Sciences, The University of Melbourne, Melbourne 3010, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Vasso Apostolopoulos
Cancers 2021, 13(23), 5925; https://doi.org/10.3390/cancers13235925 (registering DOI)
Received: 30 October 2021 / Revised: 19 November 2021 / Accepted: 19 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Feature Paper from Journal Reviewers)
Previous research supports the participation in supervised exercise among individuals with metastatic prostate cancer to help lessen the physical and psychological disease burden. However, many individuals experience considerable barriers to attending face-to-face exercise services. To overcome some of these limitations, digital interventions that can be delivered remotely have been proposed. Our pilot study investigated the acceptability, safety and preliminary efficacy of an 8-week computer-tailored web-based exercise intervention. We demonstrated that a web-based exercise program with telehealth support was acceptable and could be implemented safely. Participants in the intervention group increased their participation in moderate to vigorous physical activity compared to the control group. This study provides insight into the prospect of web-based exercise prescription for individuals with metastatic prostate cancer as an alternative for individuals who cannot access supervised exercise interventions.
Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. However, many individuals encounter barriers that limit the uptake of face-to-face exercise. Technology-enabled interventions offer a distance-based alternative. This pilot study aimed to explore the acceptability, safety and preliminary efficacy of a web-based exercise intervention (ExerciseGuide) in individuals with metastatic prostate cancer. Forty participants (70.2 ± 8.5 years) with metastatic prostate cancer were randomised into the 8-week intervention (N = 20) or a wait-list control (N = 20). The intervention arm had access to a computer-tailored website, personalised exercise prescription and remote supervision. ExerciseGuide was deemed acceptable with a score ≥20 on the client satisfaction questionnaire; however, the usability score was just below the pre-specified score of ≥68 on the software usability scale. There were no serious adverse events reported. Moderate-to-vigorous physical activity levels between baseline and follow-ups were significantly higher (10.0 min per day; 95% CI = (1.3–18.6); p = 0.01) in the intervention group compared to wait-list control. There were also greater improvements in step count (1332; 95% CI = (159–2505); p = 0.02) and identified motivation (0.4, 95% CI = (0.0, 0.7); p = 0.04). Our findings provide preliminary evidence that ExerciseGuide is acceptable, safe and efficacious among individuals with metastatic prostate cancer. View Full-Text
Keywords: exercise; metastatic prostate cancer; behavioural change; eHealth; computer-tailoring; usability; acceptability; rct exercise; metastatic prostate cancer; behavioural change; eHealth; computer-tailoring; usability; acceptability; rct
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Figure 1

MDPI and ACS Style

Evans, H.E.L.; Galvão, D.A.; Forbes, C.C.; Girard, D.; Vandelanotte, C.; Newton, R.U.; Vincent, A.D.; Wittert, G.; Kichenadasse, G.; Chambers, S.; Brook, N.; Short, C.E. Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial. Cancers 2021, 13, 5925. https://doi.org/10.3390/cancers13235925

AMA Style

Evans HEL, Galvão DA, Forbes CC, Girard D, Vandelanotte C, Newton RU, Vincent AD, Wittert G, Kichenadasse G, Chambers S, Brook N, Short CE. Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial. Cancers. 2021; 13(23):5925. https://doi.org/10.3390/cancers13235925

Chicago/Turabian Style

Evans, Holly E.L., Daniel A. Galvão, Cynthia C. Forbes, Danielle Girard, Corneel Vandelanotte, Robert U. Newton, Andrew D. Vincent, Gary Wittert, Ganessan Kichenadasse, Suzanne Chambers, Nicholas Brook, and Camille E. Short 2021. "Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial" Cancers 13, no. 23: 5925. https://doi.org/10.3390/cancers13235925

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