Next Article in Journal
Predicting Overall Survival Time in Glioblastoma Patients Using Gradient Boosting Machines Algorithm and Recursive Feature Elimination Technique
Previous Article in Journal
Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy
Systematic Review

Effect of Exercise Training on Quality of Life after Colorectal and Lung Cancer Surgery: A Meta-Analysis

1
Center for Innovative Care and Health Technology (ciTechCare), School of Health Sciences of the Polytechnic of Leiria, 2411-901 Leiria, Portugal
2
University of Coimbra, Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019), Faculty of Sport Sciences and Physical Education, 3040-248 Coimbra, Portugal
3
Laboratory of Biostatistics and Medical Informatics (LBIM), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
4
Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, 3000-548 Coimbra, Portugal
5
Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, 3000-548 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Last authors, the authors contributed equally to the manuscript.
Academic Editor: Nobuyuki Horita
Cancers 2021, 13(19), 4975; https://doi.org/10.3390/cancers13194975
Received: 15 August 2021 / Revised: 29 September 2021 / Accepted: 30 September 2021 / Published: 3 October 2021
(This article belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
Surgery is the treatment modality associated with better long-term survival in patients diagnosed with lung cancer and colorectal cancer. However, as a result of surgery, patients experience a substantial decline in health-related quality of life (HRQoL) and increased fatigue symptoms. The purpose of this systematic review was to investigate the effect of pre- and/or postoperative exercise training on HRQoL and fatigue after surgical resection for lung and colorectal cancer. Our results showed that exercise training interventions improve the physical domain of HRQoL and reduce fatigue levels after lung cancer surgery, supporting its use to optimize patients’ recovery. No benefits were found on HRQoL and fatigue after colorectal cancer surgery.
Surgical treatment affects health-related quality of life (HRQoL) and increases fatigue symptoms in patients with lung cancer (LC) and colorectal cancer (CRC). We aimed to systematically review the effect of exercise training on HRQoL and fatigue after LC and CRC surgery. Randomized controlled trials published before 21 March 2021, were searched in PubMed, Scopus, Web of Science, SPORTDiscus and PEDro. Eligible trials compared the effect of exercise interventions initiated preoperatively or in the first 3 months after surgery versus usual care on postoperative HRQoL and fatigue. Standardized mean differences (SMD) were pooled using random-effects models. Twelve studies with a total of 777 patients were included. In LC patients (10 studies, n = 651), exercise training in general led to a moderate improvement in the physical domain of HRQoL (0.68: 95% CI: [0.47; 0.89]) and a small reduction in fatigue levels after surgery (SMD = 0.28: 95% CI: [0.02; 0.53]), while no effects were found in other HRQoL domains. In CRC (two studies, n = 126), exercise training showed no effects on HRQoL and fatigue after surgery. Exercise training is an effective intervention to improve physical function and fatigue after LC surgery. Further studies are necessary to clarify the effects of exercise on HRQoL and fatigue after CRC surgery. View Full-Text
Keywords: aerobic exercise; colorectal cancer; fatigue; lung cancer; meta-analysis; prehabilitation; quality of life; rehabilitation; resistance exercise; surgical oncology aerobic exercise; colorectal cancer; fatigue; lung cancer; meta-analysis; prehabilitation; quality of life; rehabilitation; resistance exercise; surgical oncology
Show Figures

Figure 1

MDPI and ACS Style

Machado, P.; Pimenta, S.; Oliveiros, B.; Ferreira, J.P.; Martins, R.A.; Cruz, J. Effect of Exercise Training on Quality of Life after Colorectal and Lung Cancer Surgery: A Meta-Analysis. Cancers 2021, 13, 4975. https://doi.org/10.3390/cancers13194975

AMA Style

Machado P, Pimenta S, Oliveiros B, Ferreira JP, Martins RA, Cruz J. Effect of Exercise Training on Quality of Life after Colorectal and Lung Cancer Surgery: A Meta-Analysis. Cancers. 2021; 13(19):4975. https://doi.org/10.3390/cancers13194975

Chicago/Turabian Style

Machado, Pedro, Sara Pimenta, Bárbara Oliveiros, José P. Ferreira, Raul A. Martins, and Joana Cruz. 2021. "Effect of Exercise Training on Quality of Life after Colorectal and Lung Cancer Surgery: A Meta-Analysis" Cancers 13, no. 19: 4975. https://doi.org/10.3390/cancers13194975

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop