Next Article in Journal
Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis
Previous Article in Journal
Precision Postoperative Radiotherapy in Sinonasal Carcinomas after Endonasal Endoscopic Surgery
Previous Article in Special Issue
Endoscopic Ultrasound Fine-Needle Biopsy versus Fine-Needle Aspiration for Tissue Sampling of Abdominal Lymph Nodes: A Propensity Score Matched Multicenter Comparative Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 13
Issue 19
10.3390/cancers13194803
Review Report
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Precision Medicine for Colorectal Cancer with Liquid Biopsy and Immunotherapy

Cancers 2021, 13(19), 4803; https://doi.org/10.3390/cancers13194803
by Satoshi Nagayama 1,2, Siew-Kee Low 3, Kazuma Kiyotani 3 and Yusuke Nakamura 3,*
Reviewer 1: Anonymous
Reviewer 2:
Valentina De Falco
Cancers 2021, 13(19), 4803; https://doi.org/10.3390/cancers13194803
Submission received: 12 August 2021 / Revised: 19 September 2021 / Accepted: 21 September 2021 / Published: 25 September 2021
(This article belongs to the Special Issue Screening and Genetic Characterization of Colorectal Cancer: A Multi-Step Approach)

Round 1

Reviewer 1 Report

The authors presented a very broad and interesting compendium of information regarding the use of liquid biopsies and precision medicine in CRC management. 

I believe the work is sound and should be accepted to publication. In order to improve it further, I'd suggest the authors provide a comparison among the different methods listed in section 2, as well as a comparison between blood and stool samples, to help guide researchers using this information. It would also be interesting to discuss why the genes chosen to be monitored in stool differ from those used in blood based exams. 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The manuscript is well written and comprehensively illustrates the
clinical management of CRC patients and the prospects for improving it.
The references used are very well chosen and explained. In summary, the
Review identifies the imminent future in the analysis of liquid biopsy
on which important information can be obtained on the most correct
targeted molecular therapies to be administered to the patient in
association with chemo and radiotherapy. The analysis of ctDNA from
liquid biopsy will allow to identify the prognosis with greater
precision and to personalize the therapy for individual patients on the
basis of the expected response to drugs in the presence of the various
possible genetic alterations. It is also emphasized that this system
constitutes a particular advantage in the event of the development of
resistances in the perspective that the detection and analysis systems
of the ctDNA turn out to be increasingly better and more sensitive. The
sensitivity of the method has and, increased, could have an even greater
impact on the identification of minimal residual disease and its
characteristics. My only advice is to add, where possible, tables or
flowcharts representative of the different points covered in the
paragraphs to focus more immediately on the information you are reading. 

Author Response

Please see the attachment

Author Response File: Author Response.docx

Back to TopTop