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Review

Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets

1
College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, Korea
2
Department of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, Korea
3
Department of Biotechnology and Genetic Engineering, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh
4
Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemungu, Seoul 05253, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Anupam Bishayee
Cancers 2021, 13(18), 4502; https://doi.org/10.3390/cancers13184502
Received: 26 July 2021 / Revised: 2 September 2021 / Accepted: 3 September 2021 / Published: 7 September 2021
Recently, it has been found that cancer of the gastrointestinal tract, especially gastric cancer (GC), is the second most leading cause of cancer-related death globally. Extensive research has shown that most epidemiological investigations indicated the increased intake of naturally-occurring bioactive food components could decrease the gastric cancer risk. Several experimental studies have explained that the molecular mechanisms of action to prevent GC comprise induction of apoptosis, inhibition of cell proliferation, suppression of angiogenesis and metastasis, and regulation of autophagy. To provide an updated understanding of relationships between naturally occurring bioactive food components and gastric cancer, this study will be helpful for guiding and preventing gastric cancer by natural bioactive food products.
Gastric cancer, also known as stomach cancer, is a cancer that develops from the lining of the stomach. Accumulated evidence and epidemiological studies have indicated that bioactive food components from natural products play an important role in gastric cancer prevention and treatment, although its mechanism of action has not yet been elucidated. Particularly, experimental studies have shown that natural bioactive food products display a protective effect against gastric cancer via numerous molecular mechanisms, such as suppression of cell metastasis, anti-angiogenesis, inhibition of cell proliferation, induction of apoptosis, and modulation of autophagy. Chemotherapy remains the standard treatment for advanced gastric cancer along with surgery, radiation therapy, hormone therapy, as well as immunotherapy, and its adverse side effects including neutropenia, stomatitis, mucositis, diarrhea, nausea, and emesis are well documented. However, administration of naturally occurring bioactive phytochemical food components could increase the efficacy of gastric chemotherapy and other chemotherapeutic resistance. Additionally, several studies have suggested that bioactive food components with structural stability, potential bioavailability, and powerful bioactivity are important to develop novel treatment strategies for gastric cancer management, which may minimize the adverse effects. Therefore, the purpose of this review is to summarize the potential therapeutic effects of natural bioactive food products on the prevention and treatment of gastric cancer with intensive molecular mechanisms of action, bioavailability, and safety efficacy. View Full-Text
Keywords: gastric cancer; bioactive food components; autophagy; apoptosis; angiogenesis; metastasis; chemo-resistance gastric cancer; bioactive food components; autophagy; apoptosis; angiogenesis; metastasis; chemo-resistance
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MDPI and ACS Style

Kang, S.Y.; Hwang, D.; Shin, S.; Park, J.; Kim, M.; Rahman, M.H.; Rahman, M.A.; Ko, S.-G.; Kim, B. Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets. Cancers 2021, 13, 4502. https://doi.org/10.3390/cancers13184502

AMA Style

Kang SY, Hwang D, Shin S, Park J, Kim M, Rahman MH, Rahman MA, Ko S-G, Kim B. Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets. Cancers. 2021; 13(18):4502. https://doi.org/10.3390/cancers13184502

Chicago/Turabian Style

Kang, Seog Y., Dongwon Hwang, Soyoung Shin, Jinju Park, Myoungchan Kim, MD. H. Rahman, Md. A. Rahman, Seong-Gyu Ko, and Bonglee Kim. 2021. "Potential of Bioactive Food Components against Gastric Cancer: Insights into Molecular Mechanism and Therapeutic Targets" Cancers 13, no. 18: 4502. https://doi.org/10.3390/cancers13184502

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