Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total (n = 144) | Vascular Group ( n = 46) | Non-Vascular Group (n = 98) | p | |
---|---|---|---|---|
Gender | 0.538 | |||
| 76 (53%) | 26 (57%) | 50 (51%) | |
| 68 (47%) | 20 (43%) | 48 (49%) | |
Age, years, median (IQR) | 56.2 (48–66) | 54.3 (48–65) | 56.4 (49–67) | 0.5 |
Myasthenia Gravis | 39 (27%) | 6 (13%) | 33 (34%) | 0.009 |
Neoadjuvant CT | 74 (51%) | 37 (80%) | 37 (38%) | <0.001 |
Neoadjuvant RT | 6 (4%) | 1 (2%) | 5 (5%) | 0.4 |
Surgical Approach | ||||
| 85 (59%) | 26 (56.5%) | 59 (60%) | 0.014 |
12 (9%) | 0 (0%) | 12 (13%) | ||
38 (26%) | 18 (39%) | 20 (20%) | ||
3 (2%) | 2 (4.5%) | 1 (1%) | ||
6 (4%) | 0 (0%) | 6 (6%) | ||
R0 resection | 126 (87.5%) | 38 (82%) | 88 (89%) | 0.2 |
Tumor dimension, mm, median (IQR) | 80 (57–100) | 75 (60–100) | 80 (56–100) | 0.78 |
Post-operative complications | 33 (23%) | 12 (26%) | 21 (21%) | 0.53 |
Post-operative deaths | 3 (2%) | 1 (2%) | 2 (2%) | 0.98 |
Pathological Masaoka Stage | ||||
| 86 (60%) | 25 (55%) | 61 (62%) | 0.1 |
44 (30.5%) | 13 (28%) | 31(32%) | ||
14 (9.5%) | 8 (17%) | 6 (6%) | ||
WHO Classification | ||||
| 4 (3%) | 2 (4%) | 2 (2%) | 0.15 |
12 (8.5%) | 1 (2%) | 11 (11%) | ||
21 (14.5%) | 6 (13%) | 15 (15%) | ||
36 (25%) | 12 (27%) | 24 (25%) | ||
42 (29%) | 11 (25%) | 31 (32%) | ||
29 (20%) | 14 (29%) | 15 (15%) | ||
Adjuvant CT | 22 (14%) | 2 (4%) | 20 (20%) | 0.01 |
Adjuvant RT | 106 (74%) | 33 (72%) | 73 (74%) | 0.7 |
Recurrence | 57 (39.5%) | 22 (49%) | 35 (36%) | 0.15 |
| 1 (1%) | 0 (0%) | 1 (3%) | |
| 30 (53%) | 9 (41%) | 21 (60%) | |
| 26 (46%) | 13 (59%) | 13 (37%) |
Histology | Pleura | Lung | Liver | Bone | Lymp Nodes | Other | |
---|---|---|---|---|---|---|---|
Vascular Group | |||||||
| Thymic Carc. | + | |||||
| Thymoma | + | |||||
| Thymic Carc. | + | + | ||||
| Thymoma | + | + | ||||
| Thymic Carc. | + | |||||
| Thymoma | + | + | ||||
| Thymoma | + | |||||
| Thymoma | + | + | ||||
| Thymic Carc. | + | |||||
| Thymoma | + | |||||
| Thymoma | + | |||||
| Thymic Carc. | + | + | + | |||
| Thymoma | + | + | + | |||
Non Vascular Group | |||||||
| Thymoma | + | |||||
| Thymoma | + | |||||
| Thymoma | + | + | + | |||
| Thymoma | + | + | ||||
| Thymoma | + | + | ||||
| Thymic Carc. | + | + | ||||
| Thymic Carc. | + | |||||
| Thymic Carc. | + | + | ||||
| Thymoma | + | |||||
| Thymoma | + | + | + | |||
| Thymic Carc. | + | + | ||||
| Thymic Carc. | + | |||||
| Thymoma | + |
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Comacchio, G.M.; Dell’Amore, A.; Marino, M.C.; Russo, M.D.; Schiavon, M.; Mammana, M.; Faccioli, E.; Lorenzoni, G.; Gregori, D.; Pasello, G.; et al. Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes. Cancers 2021, 13, 3355. https://doi.org/10.3390/cancers13133355
Comacchio GM, Dell’Amore A, Marino MC, Russo MD, Schiavon M, Mammana M, Faccioli E, Lorenzoni G, Gregori D, Pasello G, et al. Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes. Cancers. 2021; 13(13):3355. https://doi.org/10.3390/cancers13133355
Chicago/Turabian StyleComacchio, Giovanni M., Andrea Dell’Amore, Maria Carlotta Marino, Michele Dario Russo, Marco Schiavon, Marco Mammana, Eleonora Faccioli, Giulia Lorenzoni, Dario Gregori, Giulia Pasello, and et al. 2021. "Vascular Involvement in Thymic Epithelial Tumors: Surgical and Oncological Outcomes" Cancers 13, no. 13: 3355. https://doi.org/10.3390/cancers13133355