Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Tumor Characteristics
2.3. Germline Genetic Analysis
2.4. Statistical Analysis
3. Results
3.1. General Characteristics
3.2. Tumor Characteristics
3.3. Germline Genetic Analysis
3.4. Factors Associated with High Risk of Gastric Cancer
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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EOGC | |
---|---|
Age (years) at diagnosis; median (IQR) | 44 (40–48) |
Gender, number (%): Man | 191 (61.8) |
Environmental risk factors; number (%) | |
Helicobacter pylori infection | 24/82 (29.3) |
Smokers | 77/169 (45.6) |
Moderate or high alcohol consumers | 21/105 (20) |
Personal history of extra-gastric cancer (n = 309); number (%) | |
Breast and/or ovarian | 5 (1.6) |
Lung | 1 (0.3) |
Thyroid | 1 (0.3) |
Hodgkin lymphoma | 1 (0.3) |
Cervix | 1 (0.3) |
Familial history of cancer (n = 117); number (%) | |
GC | 18 (15.4) |
Colorectal | 8 (6.8) |
Ovarian and/or breast | 15 (12.8) |
Others | 39 (33.3) |
Criteria of familial GC | 5 (4.3) |
EOGC | |
---|---|
Gastric location (N = 203); number (%) | |
Cardias | 3 (1.5) |
Fundus | 18 (8.9) |
Body | 111 (54.7) |
Antrum | 50 (24.6) |
Extensive | 21 (10.3) |
Stage (N = 212); number (%) | |
I/II | 44 (20.8) |
III/IV | 166 (78.3) |
Histology (N = 161); number (%) | |
(a) Diffuse Signet ring cell subset | 118 (73.3) 38/118 (32.2) |
(b) Intestinal | 30 (18.6) |
(c) Mixed | 13 (8.1) |
Tumor differentiation grade (N = 23/43) number (%) * | |
High grade (poorly differentiated) | 9 (39.1) |
Low-grade (well/moderately differentiated) | 14 (60.9) |
Treatment (N = 205) number (%) | |
Surgery | 40 (19.5) |
Surgery + chemotherapy | 58 (31.2) |
Chemotherapy | 64 (28.3) |
Surgery + chemotherapy + radiotherapy | 24 (11.7) |
Chemotherapy + radiotherapy | 3 (1.5) |
Palliative | 16 (7.8) |
Patient | Age | Gender | Tumor Characteristics | H. pylori Infection | Personal History of Other Tumors | Familial History of GC | Familial History of Other Tumors | MMR-IHC | Gene (Pathogenic Variant) |
---|---|---|---|---|---|---|---|---|---|
1 | 49 | Woman | Intestinal hist. Stage II | Not available | Breast | No | Ovarian and breast | MMR+ (normal) | BRCA2 (c.3166C>T; p.Gln1056 *; nonsense) |
2 | 38 | Man | Diffuse hist. Multifocal (plastic linitis) Stage IV | No | No | Yes | No | MMR+ (normal) | CDH1 (c.2164+5G>C; splicing) |
3 | 34 | Man | Diffuse hist. Multifocal (plastic linitis) Stage IV | No | No | No | Breast and colorectal | MMR+ (normal) | TP53 (c.365_366delTG; p.Val122fs; frameshift) |
4 | 40 | Man | Diffuse hist. Multifocal (plastic linitis) Stage IV | No | No | Yes | No | MMR+ (normal) | CDH1 (c.187C>T; p.Arg63 *; nonsense) |
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Pocurull, A.; Herrera-Pariente, C.; Carballal, S.; Llach, J.; Sánchez, A.; Carot, L.; Botargues, J.M.; Cuatrecasas, M.; Ocaña, T.; Balaguer, F.; et al. Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study. Cancers 2021, 13, 3132. https://doi.org/10.3390/cancers13133132
Pocurull A, Herrera-Pariente C, Carballal S, Llach J, Sánchez A, Carot L, Botargues JM, Cuatrecasas M, Ocaña T, Balaguer F, et al. Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study. Cancers. 2021; 13(13):3132. https://doi.org/10.3390/cancers13133132
Chicago/Turabian StylePocurull, Anna, Cristina Herrera-Pariente, Sabela Carballal, Joan Llach, Ariadna Sánchez, Laura Carot, Josep María Botargues, Miriam Cuatrecasas, Teresa Ocaña, Francesc Balaguer, and et al. 2021. "Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study" Cancers 13, no. 13: 3132. https://doi.org/10.3390/cancers13133132