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Review

Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer

1
Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK
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Department of Physics, University of Surrey, Guildford GU2 7XH, UK
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Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK
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Centre for 3D Models of Health and Disease, UCL-Division of Surgery and Interventional Science, Charles Bell House, 43-45 Foley Street, Fitzrovia, London W1W 7TY, UK
5
National Physical Laboratory, Teddington TW11 0LW, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Zhixiang Wang
Cancers 2021, 13(12), 2940; https://doi.org/10.3390/cancers13122940
Received: 10 May 2021 / Revised: 7 June 2021 / Accepted: 8 June 2021 / Published: 11 June 2021
(This article belongs to the Collection Drug Resistance and Novel Therapies in Cancers)
Pancreatic cancer is a disease of unmet clinical needs. Considering the poor prognosis and high treatment resistance of this devastating disease, the search for the development, understanding and characterization of potential treatments and/or treatment sensitizers is of clinical importance. The synergy between natural remedies and state-of-the-art cancer treatments has been poorly considered despite evidence of antioxidant, antimicrobial and antitumor capabilities. Moreover, natural chemical compounds have been the source of many approved drugs. This review collates novel and natural compounds explored for their preclinical anticancer, chemosensitizing and radiosensitizing effects for pancreatic cancer. Here, we highlight a number of natural sources in very early preclinical testing that may hold potential to enhance treatment sensitization, and in turn, reduce treatment resistance and toxicity via lowering treatment dose requirements.
The isolation of chemical compounds from natural origins for medical application has played an important role in modern medicine with a range of novel treatments having emerged from various natural forms over the past decades. Natural compounds have been exploited for their antioxidant, antimicrobial and antitumor capabilities. Specifically, 60% of today’s anticancer drugs originate from natural sources. Moreover, the combination of synthetic and natural treatments has shown applications for (i) reduced side effects, (ii) treatment sensitization and (iii) reduction in treatment resistance. This review aims to collate novel and natural compounds that are being explored for their preclinical anticancer, chemosensitizing and radiosensitizing effects on Pancreatic Ductal Adenocarcinoma (PDAC), which is a lethal disease with current treatments being inefficient and causing serve side effects. Two key points are highlighted by this work: (i) the availability of a range of natural compounds for potentially new therapeutic approaches for PDAC, (ii) potential synergetic impact of natural compounds with advanced chemo- and radio-therapeutic modalities for PDAC. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; pancreatic cancer; radiotherapy; tumor microenvironment; natural components; anticancer components; chemosensitizer; radiosensitizer pancreatic ductal adenocarcinoma; pancreatic cancer; radiotherapy; tumor microenvironment; natural components; anticancer components; chemosensitizer; radiosensitizer
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MDPI and ACS Style

Wishart, G.; Gupta, P.; Nisbet, A.; Velliou, E.; Schettino, G. Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer. Cancers 2021, 13, 2940. https://doi.org/10.3390/cancers13122940

AMA Style

Wishart G, Gupta P, Nisbet A, Velliou E, Schettino G. Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer. Cancers. 2021; 13(12):2940. https://doi.org/10.3390/cancers13122940

Chicago/Turabian Style

Wishart, Gabrielle, Priyanka Gupta, Andrew Nisbet, Eirini Velliou, and Giuseppe Schettino. 2021. "Novel Anticancer and Treatment Sensitizing Compounds against Pancreatic Cancer" Cancers 13, no. 12: 2940. https://doi.org/10.3390/cancers13122940

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