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Article

Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study

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Unit of Cancer Survivorship, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
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Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
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Medical Faculty Heidelberg, University of Heidelberg, 69120 Heidelberg, Germany
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Cancer Registry of North Rhine-Westphalia, 44801 Bochum, Germany
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Bremen Cancer Registry, Leibniz Institute for Prevention Research and Epidemiology—BIPS, 28359 Bremen, Germany
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Saarland Cancer Registry, 66024 Saarbrücken, Germany
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Hamburg Cancer Registry, 20539 Hamburg, Germany
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Cancer Registry of Schleswig-Holstein, 23538 Lübeck, Germany
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Institute for Social Medicine and Epidemiology, University of Lübeck, 23538 Lübeck, Germany
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Cancer Registry of Rhineland-Palatinate, 55116 Mainz, Germany
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Division of Preventive Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
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German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Saskia F. A. Duijts and Evelien R. Spelten
Cancers 2021, 13(11), 2754; https://doi.org/10.3390/cancers13112754
Received: 15 April 2021 / Revised: 25 May 2021 / Accepted: 28 May 2021 / Published: 1 June 2021
(This article belongs to the Special Issue Cancer Survivorship)
Little is known about the health-related quality of life in very long-term cancer survivors 10 and more years post-diagnosis. Therefore, we compared the health-related quality of life of survivors of breast, colorectal, and prostate cancer (14–24 years post-diagnosis) with that of same-aged non-cancer controls, according to age, sex, and disease status (disease-free vs. stage IV, recurrence, metastasis, or second cancer). We found that the overall global health status/quality of life of cancer survivors more than a decade after diagnosis was slightly higher than that of population controls of the same age, but more symptoms and lower functioning were reported. Differences were small but statistically significant. Results differed by age, sex, and disease status. The findings point out the need for a comprehensive survivorship care program in order to monitor and treat potential late and long-term effects after the diagnosis and treatment of cancer. Survivorship care should be risk-adapted to survivors’ needs according to sociodemographic and clinical factors.
(1) Background: Little is known about the health-related quality of life (HRQoL) in very long-term cancer survivors (VLTCS) 10 and more years post-diagnosis. The objective was to compare cancer survivors’ HRQoL 14–24 years post-diagnosis with that of same-aged non-cancer controls, stratified by age, sex, and disease status (disease-free vs. stage IV, recurrence, metastasis, or second cancer). (2) Methods: We recruited 2704 very long-term survivors of breast, colorectal and prostate cancer, and 1765 controls in German multi-regional population-based studies. The HRQoL was assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30). Differences in the HRQoL were estimated with multiple regression, controlling for age, sex (where appropriate), and education. (3) Results: The overall global health status/quality of life of VLTCS more than a decade after diagnosis was slightly higher than that of population controls of the same age, but more symptoms and lower functioning were reported. Differences were small but statistically significant. Results differed by age, sex, and disease status. (4) Conclusions: The findings point out the need for a comprehensive survivorship care program in order to monitor and treat potential late and long-term effects after the diagnosis and treatment of cancer. Survivorship care should be risk-adapted to survivors’ needs according to sociodemographic and clinical factors. View Full-Text
Keywords: cancer survivorship; health-related quality of life; population-based; long-term effects; age effects cancer survivorship; health-related quality of life; population-based; long-term effects; age effects
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MDPI and ACS Style

Doege, D.; Thong, M.S.Y.; Weißer, L.; Koch-Gallenkamp, L.; Jansen, L.; Bertram, H.; Eberle, A.; Holleczek, B.; Nennecke, A.; Pritzkuleit, R.; Waldmann, A.; Zeissig, S.R.; Brenner, H.; Arndt, V. Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study. Cancers 2021, 13, 2754. https://doi.org/10.3390/cancers13112754

AMA Style

Doege D, Thong MSY, Weißer L, Koch-Gallenkamp L, Jansen L, Bertram H, Eberle A, Holleczek B, Nennecke A, Pritzkuleit R, Waldmann A, Zeissig SR, Brenner H, Arndt V. Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study. Cancers. 2021; 13(11):2754. https://doi.org/10.3390/cancers13112754

Chicago/Turabian Style

Doege, Daniela, Melissa S.Y. Thong, Linda Weißer, Lena Koch-Gallenkamp, Lina Jansen, Heike Bertram, Andrea Eberle, Bernd Holleczek, Alice Nennecke, Ron Pritzkuleit, Annika Waldmann, Sylke R. Zeissig, Hermann Brenner, and Volker Arndt. 2021. "Health-Related Quality of Life in Very Long-Term Cancer Survivors 14–24 Years Post-Diagnosis Compared to Population Controls: A Population-Based Study" Cancers 13, no. 11: 2754. https://doi.org/10.3390/cancers13112754

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