Next Article in Journal
Neuroendocrine Lung Cancer Mouse Models: An Overview
Previous Article in Journal
Pathogenetic Role and Clinical Implications of Regulatory RNAs in Biliary Tract Cancer
Review

The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

1
Department of Internal Medicine, University of Michigan Health System, Internal Medicine, Ann Arbor, MI 48109, USA
2
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
*
Author to whom correspondence should be addressed.
Cancers 2021, 13(1), 13; https://doi.org/10.3390/cancers13010013
Received: 7 October 2020 / Revised: 23 November 2020 / Accepted: 9 December 2020 / Published: 22 December 2020
Lung cancer is the major cause of cancer related deaths in the world. New therapies have improved outcomes. Unfortunately, overall 5 year survival is ~20%. Therefore, better understanding of tumor biology and the microenvironment may lead to new therapeutic targets. The lung microbiome has recently emerged as a major mediator of host inflammation and pathogenesis. Understanding how the lung microbiota exerts its effects on lung cancer and the tumor microenvironment will allow for novel development of therapies.
Lung cancer is the leading cause of cancer-related death. Over the past 5–10 years lung cancer outcomes have significantly improved in part due to better treatment options including immunotherapy and molecularly targeted agents. Unfortunately, the majority of lung cancer patients do not enjoy durable responses to these new treatments. Seminal research demonstrated the importance of the gut microbiome in dictating responses to immunotherapy in melanoma patients. However, little is known regarding how other sites of microbiota in the human body affect tumorigenesis and treatment responses. The lungs were traditionally thought to be a sterile environment; however, recent research demonstrated that the lung contains its own dynamic microbiota that can influence disease and pathophysiology. Few studies have explored the role of the lung microbiome in lung cancer biology. In this review article, we discuss the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention. View Full-Text
Keywords: lung cancer; lung microbiome; metabolism; tumor microenvironment; inflammation; immunity lung cancer; lung microbiome; metabolism; tumor microenvironment; inflammation; immunity
Show Figures

Figure 1

MDPI and ACS Style

Weinberg, F.; Dickson, R.P.; Nagrath, D.; Ramnath, N. The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? Cancers 2021, 13, 13. https://doi.org/10.3390/cancers13010013

AMA Style

Weinberg F, Dickson RP, Nagrath D, Ramnath N. The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients? Cancers. 2021; 13(1):13. https://doi.org/10.3390/cancers13010013

Chicago/Turabian Style

Weinberg, Frank, Robert P. Dickson, Deepak Nagrath, and Nithya Ramnath. 2021. "The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?" Cancers 13, no. 1: 13. https://doi.org/10.3390/cancers13010013

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop