Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Results from the Literature Search
2.2. Results from the Trials Included
2.3. Meta-Analysis of Randomized Trials
2.4. Immune-Related Features in TNBC
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Study | Treatment | pCR Rates (N. of pts) |
---|---|---|
KEYNOTE-173, open label, phase Ib | Cohort A: P/nab-pac→P/AC Cohort B: P/nab-pac/Cb q3wks→P/AC Cohort C: P/nab-pac/Cb q3wks→P/AC Cohort D: P/nab-pac/Cb q1wk→P/AC Cohort E: P/pac/Cb q3wks→P/AC Cohort F: P/pac/Cb q1wk→P/AC | 60% (6/10) 60% (6/10) 80% (8/10) 60% (6/10) 30% (3/10) 50% (5/10) |
I-SPY2, randomized, phase II | Exp. arm: P/pac→P/AC Control arm: pac→AC | 68% (19/28) 23% (18/79) |
KEYNOTE-522, randomized, phase III | Exp. arm: P/Cb/pac→P/AC or P/EC, adj. P Control arm: plac/Cb/pac→plac/AC or plac/EC, adj. plac | 64.8% (260/401) 51.2% (103/201) |
GeparNuevo, randomized, phase II | Exp. arm: D→D/nab-pac→D/EC Control arm: plac→plac/nab-pac→plac/EC | 53.4% (47/88) 44.2% (38/86) |
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Marinelli, D.; Mazzotta, M.; Pizzuti, L.; Krasniqi, E.; Gamucci, T.; Natoli, C.; Grassadonia, A.; Tinari, N.; Tomao, S.; Sperduti, I.; et al. Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials. Cancers 2020, 12, 2497. https://doi.org/10.3390/cancers12092497
Marinelli D, Mazzotta M, Pizzuti L, Krasniqi E, Gamucci T, Natoli C, Grassadonia A, Tinari N, Tomao S, Sperduti I, et al. Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials. Cancers. 2020; 12(9):2497. https://doi.org/10.3390/cancers12092497
Chicago/Turabian StyleMarinelli, Daniele, Marco Mazzotta, Laura Pizzuti, Eriseld Krasniqi, Teresa Gamucci, Clara Natoli, Antonino Grassadonia, Nicola Tinari, Silverio Tomao, Isabella Sperduti, and et al. 2020. "Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials" Cancers 12, no. 9: 2497. https://doi.org/10.3390/cancers12092497