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Review

Immunoradiotherapy as an Effective Therapeutic Strategy in Lung Cancer: From Palliative Care to Curative Intent

1
Department of Radiation Oncology, Dr Negrin University Hospital of Gran Canaria, Barranco de la Ballena S/N, Planta 2, 35010 Las Palmas de Gran Canaria, Spain
2
Department of Radiation Oncology, IMED Hospitales, Avenida Nueva Condomina 11, 30110 Murcia, Spain
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Department of Radiation Oncology, Nisa-Vithas Virgen del Consuelo Hospital, Callosa d’en Sarrià 12, 46007 Valencia, Spain
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Department of Medical Oncology, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Calle Francisco Hernández González 1, 35016 Las Palmas de Gran Canaria, Spain
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Clinical Deparment, Faculty of Biomedicine, Universidad de las Palmas de Gran Canaria, Calle Juan de Quesada 30, 35001 Las Palmas de Gran Canaria, Spain
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Department of Radiation Oncology, Quirónsalud Madrid University Hospital, Calle Diego de Velázquez 1, 28223 Pozuelo de Alarcón, Madrid, Spain
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Department of Radiation Oncology, La Luz Hospital, Calle Maestro Ángel Llorca 8, 28003 Madrid, Spain
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Clinical Deparment, Faculty of Biomedicine, Universidad Europea de Madrid, Calle Tajo, S/N, 28670 Villaviciosa de Odón, Madrid, Spain
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(8), 2178; https://doi.org/10.3390/cancers12082178
Received: 14 July 2020 / Revised: 2 August 2020 / Accepted: 3 August 2020 / Published: 5 August 2020
(This article belongs to the Special Issue Cancer Radiotherapy)
Lung cancer is one of the main causes of cancer-related mortality worldwide. Over the years, different therapeutic modalities have been adopted depending on tumor stage and patient characteristics, such as surgery, radiotherapy (RT), and chemotherapy. Recently, with the development of immune-checkpoint inhibitors (ICI), the treatment of metastatic and locally advanced non-small cell lung cancer (NSCLC) has experienced a revolution that has resulted in a significant improvement in overall survival with an enhanced toxicity profile. Despite this paradigm shift, most patients present some kind of resistance to ICI. In this setting, current research is shifting towards the integration of multiple therapies, with RT and ICI being one of the most promising based on the potential immunostimulatory synergy of this combination. This review gives an overview of the evolution and current state of the combination of RT and ICI and provides evidence-based data that can improve patient selection. The combination in lung cancer is a safe therapeutic approach that improves local control and progression-free survival, and it has the potential to unleash abscopal responses. Additionally, this treatment strategy seems to be able to re-sensitize select patients that have reached a state of resistance to ICI, further enabling the continuation of systemic therapy. View Full-Text
Keywords: lung cancer; radiotherapy; immunotherapy; immune-checkpoint inhibitors; abscopal effect lung cancer; radiotherapy; immunotherapy; immune-checkpoint inhibitors; abscopal effect
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MDPI and ACS Style

Chicas-Sett, R.; Zafra-Martin, J.; Morales-Orue, I.; Castilla-Martinez, J.; Berenguer-Frances, M.A.; Gonzalez-Rodriguez, E.; Rodriguez-Abreu, D.; Couñago, F. Immunoradiotherapy as an Effective Therapeutic Strategy in Lung Cancer: From Palliative Care to Curative Intent. Cancers 2020, 12, 2178. https://doi.org/10.3390/cancers12082178

AMA Style

Chicas-Sett R, Zafra-Martin J, Morales-Orue I, Castilla-Martinez J, Berenguer-Frances MA, Gonzalez-Rodriguez E, Rodriguez-Abreu D, Couñago F. Immunoradiotherapy as an Effective Therapeutic Strategy in Lung Cancer: From Palliative Care to Curative Intent. Cancers. 2020; 12(8):2178. https://doi.org/10.3390/cancers12082178

Chicago/Turabian Style

Chicas-Sett, Rodolfo, Juan Zafra-Martin, Ignacio Morales-Orue, Juan Castilla-Martinez, Miguel A. Berenguer-Frances, Elisa Gonzalez-Rodriguez, Delvys Rodriguez-Abreu, and Felipe Couñago. 2020. "Immunoradiotherapy as an Effective Therapeutic Strategy in Lung Cancer: From Palliative Care to Curative Intent" Cancers 12, no. 8: 2178. https://doi.org/10.3390/cancers12082178

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