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Article

Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome

1
Faculty of Biochemistry and Molecular Medicine, University of Oulu, FI-90014 Oulu, Finland
2
Finnish Cancer Institute, 00130 Helsinki, Finland
3
Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA
4
University of Illinois Cancer Center, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(8), 2046; https://doi.org/10.3390/cancers12082046
Received: 24 June 2020 / Revised: 17 July 2020 / Accepted: 22 July 2020 / Published: 24 July 2020
(This article belongs to the Collection Matrix Effectors and Cancer)
The extracellular matrix (ECM) is a master regulator of all cellular functions and a major component of the tumor microenvironment. We previously defined the “matrisome” as the ensemble of genes encoding ECM proteins and proteins modulating ECM structure or function. While compositional and biomechanical changes in the ECM regulate cancer progression, no study has investigated the genomic alterations of matrisome genes in cancers and their consequences. Here, mining The Cancer Genome Atlas (TCGA) data, we found that copy number alterations and mutations are frequent in matrisome genes, even more so than in the rest of the genome. We also found that these alterations are predicted to significantly impact gene expression and protein function. Moreover, we identified matrisome genes whose mutational burden is an independent predictor of survival. We propose that studying genomic alterations of matrisome genes will further our understanding of the roles of this compartment in cancer progression and will lead to the development of innovative therapeutic strategies targeting the ECM. View Full-Text
Keywords: extracellular matrix; tumor microenvironment; copy number alterations; mutations; protein domains; survival extracellular matrix; tumor microenvironment; copy number alterations; mutations; protein domains; survival
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MDPI and ACS Style

Izzi, V.; Davis, M.N.; Naba, A. Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome. Cancers 2020, 12, 2046. https://doi.org/10.3390/cancers12082046

AMA Style

Izzi V, Davis MN, Naba A. Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome. Cancers. 2020; 12(8):2046. https://doi.org/10.3390/cancers12082046

Chicago/Turabian Style

Izzi, Valerio, Martin N. Davis, and Alexandra Naba. 2020. "Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome" Cancers 12, no. 8: 2046. https://doi.org/10.3390/cancers12082046

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