Emerging Contribution of PancRNAs in Cancer
Abstract
:1. Introduction
2. Role of PancRNAs in Neoplastic Transformation
2.1. PancRNAs Support Cell Proliferation
2.2. PancRNAs Counteract Antiproliferative Signals
2.3. PancRNAs Favor Apoptosis Escaping
2.4. PancRNAs Favor Unlimited Replicative Potential
2.5. PancRNAs Sustain Angiogenesis
2.6. PancRNAs Contribute to Tissue Invasion and Metastasis
3. Mechanisms of Action of PancRNAs
4. Therapeutic Targeting: Lessons from PancRNAs
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
- Hanahan, D.; Weinberg, R.A. The hallmarks of cancer. Cell 2000, 100, 57–70. [Google Scholar] [CrossRef] [Green Version]
- Morris, K.V.; Mattick, J.S. The rise of regulatory RNA. Nat. Rev. Genet. 2014, 15, 423–437. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Djebali, S.; Davis, C.A.; Merkel, A.; Dobin, A.; Lassmann, T.; Mortazavi, A.; Tanzer, A.; Lagarde, J.; Lin, W.; Schlesinger, F.; et al. Landscape of transcription in human cells. Nature 2012, 489, 101–108. [Google Scholar] [CrossRef] [PubMed]
- Mattick, J.S. A new paradigm for developmental biology. J. Exp. Biol. 2007, 210, 1526–1547. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ulitsky, I.; Shkumatava, A.; Jan, C.H.; Sive, H.; Bartel, D.P. Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution. Cell 2011, 147, 1537–1550. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Quinn, J.J.; Zhang, Q.C.; Georgiev, P.; Ilik, I.A.; Akhtar, A.; Chang, H.Y. Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes Dev. 2016, 30, 191–207. [Google Scholar] [CrossRef] [Green Version]
- Huarte, M.; Guttman, M.; Feldser, D.; Garber, M.; Koziol, M.J.; Kenzelmann-Broz, D.; Khalil, A.M.; Zuk, O.; Amit, I.; Rabani, M.; et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010, 142, 409–419. [Google Scholar] [CrossRef] [Green Version]
- Zheng, G.X.; Do, B.T.; Webster, D.E.; Khavari, P.A.; Chang, H.Y. Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs. Nat. Struct. Mol. Biol. 2014, 21, 585–590. [Google Scholar] [CrossRef] [Green Version]
- Calin, G.A.; Liu, C.G.; Ferracin, M.; Hyslop, T.; Spizzo, R.; Sevignani, C.; Fabbri, M.; Cimmino, A.; Lee, E.J.; Wojcik, S.E.; et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 2007, 12, 215–229. [Google Scholar] [CrossRef]
- Guttman, M.; Amit, I.; Garber, M.; French, C.; Lin, M.F.; Feldser, D.; Huarte, M.; Zuk, O.; Carey, B.W.; Cassady, J.P.; et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009, 458, 223–227. [Google Scholar] [CrossRef] [PubMed]
- Core, L.J.; Waterfall, J.J.; Lis, J.T. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 2008, 322, 1845–1848. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Seila, A.C.; Core, L.J.; Lis, J.T.; Sharp, P.A. Divergent transcription: A new feature of active promoters. Cell Cycle 2009, 8, 2557–2564. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Kapranov, P.; Cheng, J.; Dike, S.; Nix, D.A.; Duttagupta, R.; Willingham, A.T.; Stadler, P.F.; Hertel, J.; Hackermüller, J.; Hofacker, I.L.; et al. RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 2007, 316, 1484–1488. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Martens, J.A.; Laprade, L.; Winston, F. Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene. Nature 2004, 429, 571–574. [Google Scholar] [CrossRef]
- Kato, Y.; Perez, C.A.G.; Mohamad Ishak, N.S.; Nong, Q.D.; Sudo, Y.; Matsuura, T.; Wada, T.; Watanabe, H. A 5′ UTR-Overlapping LncRNA Activates the Male-Determining Gene doublesex1 in the Crustacean Daphnia magna. Curr. Biol. 2018, 28, 1811–1817.e1814. [Google Scholar] [CrossRef] [Green Version]
- Goh, K.Y.; Inoue, T. A large transcribed enhancer region regulates C. elegans bed-3 and the development of egg laying muscles. Biochim. Biophys. Acta Gene. Regul. Mech. 2018, 1861, 519–533. [Google Scholar] [CrossRef]
- Schor, I.E.; Bussotti, G.; Maleš, M.; Forneris, M.; Viales, R.R.; Enright, A.J.; Furlong, E.E.M. Non-coding RNA Expression, Function, and Variation during Drosophila Embryogenesis. Curr. Biol. 2018, 28, 3547–3561. [Google Scholar] [CrossRef]
- Guil, S.; Esteller, M. Cis-acting noncoding RNAs: Friends and foes. Nat. Struct. Mol. Biol. 2012, 19, 1068–1075. [Google Scholar] [CrossRef]
- Chellini, L.; Frezza, V.; Paronetto, M.P. Dissecting the transcriptional regulatory networks of promoter-associated noncoding RNAs in development and cancer. J. Exp. Clin. Cancer Res. 2020, 39, 1–10. [Google Scholar] [CrossRef] [Green Version]
- Han, J.; Kim, D.; Morris, K.V. Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells. Proc. Natl. Acad. Sci. USA 2007, 104, 12422–12427. [Google Scholar] [CrossRef] [Green Version]
- Wang, X.; Arai, S.; Song, X.; Reichart, D.; Du, K.; Pascual, G.; Tempst, P.; Rosenfeld, M.G.; Glass, C.K.; Kurokawa, R. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 2008, 454, 126–130. [Google Scholar] [CrossRef]
- Palombo, R.; Frisone, P.; Fidaleo, M.; Mercatelli, N.; Sette, C.; Paronetto, M.P. The Promoter-Associated Noncoding RNA. Cancer Res. 2019, 79, 3570–3582. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Svetoni, F.; Frisone, P.; Paronetto, M.P. Role of FET proteins in neurodegenerative disorders. RNA Biol. 2016, 13, 1089–1102. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yoneda, R.; Ueda, N.; Uranishi, K.; Hirasaki, M.; Kurokawa, R. Long noncoding RNA. J. Biol. Chem. 2020, 295, 5626–5639. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yoneda, R.; Suzuki, S.; Mashima, T.; Kondo, K.; Nagata, T.; Katahira, M.; Kurokawa, R. The binding specificity of Translocated in LipoSarcoma/FUsed in Sarcoma with lncRNA transcribed from the promoter region of cyclin D1. Cell Biosci. 2016, 6, 1–12. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cui, W.; Yoneda, R.; Ueda, N.; Kurokawa, R. Arginine methylation of translocated in liposarcoma (TLS) inhibits its binding to long noncoding RNA, abrogating TLS-mediated repression of CBP/p300 activity. J. Biol. Chem. 2018, 293, 10937–10948. [Google Scholar] [CrossRef] [Green Version]
- Toomey, E.C.; Schiffman, J.D.; Lessnick, S.L. Recent advances in the molecular pathogenesis of Ewing’s sarcoma. Oncogene 2010, 29, 4504–4516. [Google Scholar] [CrossRef] [Green Version]
- Selvanathan, S.P.; Graham, G.T.; Erkizan, H.V.; Dirksen, U.; Natarajan, T.G.; Dakic, A.; Yu, S.; Liu, X.; Paulsen, M.T.; Ljungman, M.E.; et al. Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. Proc. Natl. Acad. Sci. USA 2015, 112, E1307–E1316. [Google Scholar] [CrossRef] [Green Version]
- Fidaleo, M.; Svetoni, F.; Volpe, E.; Miñana, B.; Caporossi, D.; Paronetto, M.P. Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9. Oncotarget 2015, 6, 31740–31757. [Google Scholar] [CrossRef] [Green Version]
- Fidaleo, M.; De Paola, E.; Paronetto, M.P. The RNA helicase A in malignant transformation. Oncotarget 2016, 7, 28711–28723. [Google Scholar] [CrossRef] [Green Version]
- Dauphinot, L.; De Oliveira, C.; Melot, T.; Sévenet, N.; Thomas, V.; E Weissman, B.; Delattre, O. Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2 and c-Myc expression. Oncogene 2001, 20, 3258–3265. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Busà, R.; Paronetto, M.P.; Farini, D.; Pierantozzi, E.; Botti, F.; Angelini, D.F.; Attisani, F.; Vespasiani, G.; Sette, C. The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 2007, 26, 4372–4382. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Paronetto, M.P.; Cappellari, M.; Busà, R.; Pedrotti, S.; Vitali, R.; Comstock, C.; Hyslop, T.; Knudsen, K.E.; Sette, C. Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68. Cancer Res. 2010, 70, 229–239. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Frisone, P.; Pradella, D.; Di Matteo, A.; Belloni, E.; Ghigna, C.; Paronetto, M.P. SAM68: Signal Transduction and RNA Metabolism in Human Cancer. Biomed. Res. Int. 2015, 2015, 528954. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Adhikary, S.; Eilers, M. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 2005, 6, 635–645. [Google Scholar] [CrossRef] [PubMed]
- Foley, K.P.; McArthur, G.A.; Quéva, C.; Hurlin, P.J.; Soriano, P.; Eisenman, R.N. Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J. 1998, 17, 774–785. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Civenni, G.; Malek, A.; Albino, D.; Garcia-Escudero, R.; Napoli, S.; Di Marco, S.; Pinton, S.; Sarti, M.; Carbone, G.M.; Catapano, C.V. RNAi-mediated silencing of Myc transcription inhibits stem-like cell maintenance and tumorigenicity in prostate cancer. Cancer Res. 2013, 73, 6816–6827. [Google Scholar] [CrossRef] [Green Version]
- Napoli, S.; Pastori, C.; Magistri, M.; Carbone, G.M.; Catapano, C.V. Promoter-specific transcriptional interference and c-myc gene silencing by siRNAs in human cells. EMBO J. 2009, 28, 1708–1719. [Google Scholar] [CrossRef]
- Ali, S.; Coombes, R.C. Endocrine-responsive breast cancer and strategies for combating resistance. Nat. Rev. Cancer 2002, 2, 101–112. [Google Scholar] [CrossRef]
- Katzenellenbogen, B.S.; Kendra, K.L.; Norman, M.J.; Berthois, Y. Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. Cancer Res. 1987, 47, 4355–4360. [Google Scholar]
- Jeng, M.H.; Shupnik, M.A.; Bender, T.P.; Westin, E.H.; Bandyopadhyay, D.; Kumar, R.; Masamura, S.; Santen, R.J. Estrogen receptor expression and function in long-term estrogen-deprived human breast cancer cells. Endocrinology 1998, 139, 4164–4174. [Google Scholar] [CrossRef]
- Tomita, S.; Abdalla, M.O.A.; Fujiwara, S.; Matsumori, H.; Maehara, K.; Ohkawa, Y.; Iwase, H.; Saitoh, N.; Nakao, M. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation. Nat. Commun. 2015, 6, 1–15. [Google Scholar] [CrossRef]
- Abdalla, M.O.A.; Yamamoto, T.; Maehara, K.; Nogami, J.; Ohkawa, Y.; Miura, H.; Poonperm, R.; Hiratani, I.; Nakayama, H.; Nakao, M.; et al. The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis. Nat. Commun. 2019, 10, 1–15. [Google Scholar] [CrossRef] [Green Version]
- Postepska-Igielska, A.; Giwojna, A.; Gasri-Plotnitsky, L.; Schmitt, N.; Dold, A.; Ginsberg, D.; Grummt, I. LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure. Mol. Cell 2015, 60, 626–636. [Google Scholar] [CrossRef]
- Felsenfeld, G.; Rich, A. Studies on the formation of two- and three-stranded polyribonucleotides. Biochim. Biophys. Acta 1957, 26, 457–468. [Google Scholar] [CrossRef]
- Kapitonov, D.; Allegood, J.C.; Mitchell, C.; Hait, N.C.; Almenara, J.A.; Adams, J.K.; Zipkin, R.E.; Dent, P.; Kordula, T.; Milstien, S.; et al. Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts. Cancer Res. 2009, 69, 6915–6923. [Google Scholar] [CrossRef] [Green Version]
- Blasco, M.A. Telomeres and human disease: Ageing, cancer and beyond. Nat. Rev. Genet. 2005, 6, 611–622. [Google Scholar] [CrossRef]
- Kim, N.W.; Piatyszek, M.A.; Prowse, K.R.; Harley, C.B.; West, M.D.; Ho, P.L.; Coviello, G.M.; Wright, W.E.; Weinrich, S.L.; Shay, J.W. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266, 2011–2015. [Google Scholar] [CrossRef]
- Zhu, J.; Zhao, Y.; Wang, S. Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell 2010, 1, 22–32. [Google Scholar] [CrossRef] [Green Version]
- Huang, F.W.; Hodis, E.; Xu, M.J.; Kryukov, G.V.; Chin, L.; Garraway, L.A. Highly recurrent TERT promoter mutations in human melanoma. Science 2013, 339, 957–959. [Google Scholar] [CrossRef] [Green Version]
- Horn, S.; Figl, A.; Rachakonda, P.S.; Fischer, C.; Sucker, A.; Gast, A.; Kadel, S.; Moll, I.; Nagore, E.; Hemminki, K.; et al. TERT promoter mutations in familial and sporadic melanoma. Science 2013, 339, 959–961. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Killela, P.J.; Reitman, Z.J.; Jiao, Y.; Bettegowda, C.; Agrawal, N.; Diaz, L.A.; Friedman, A.H.; Friedman, H.; Gallia, G.L.; Giovanella, B.C.; et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc. Natl. Acad. Sci. USA 2013, 110, 6021–6026. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Malhotra, S.; Freeberg, M.A.; Winans, S.J.; Taylor, J.; Beemon, K.L. A Novel Long Non-Coding RNA in the hTERT Promoter Region Regulates hTERT Expression. Noncoding RNA 2017, 4, 1. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Han, B.; Bhowmick, N.; Qu, Y.; Chung, S.; Giuliano, A.E.; Cui, X. FOXC1: An emerging marker and therapeutic target for cancer. Oncogene 2017, 36, 3957–3963. [Google Scholar] [CrossRef] [Green Version]
- Kong, X.P.; Yao, J.; Luo, W.; Feng, F.K.; Ma, J.T.; Ren, Y.P.; Wang, D.L.; Bu, R.F. The expression and functional role of a FOXC1 related mRNA-lncRNA pair in oral squamous cell carcinoma. Mol. Cell. Biochem. 2014, 394, 177–186. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Liu, J.; Shen, L.; Yao, J.; Li, Y.; Wang, Y.; Chen, H.; Geng, P. Forkhead box C1 promoter upstream transcript, a novel long non-coding RNA, regulates proliferation and migration in basal-like breast cancer. Mol. Med. Rep. 2015, 11, 3155–3159. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Pan, F.; Yao, J.; Chen, Y.; Zhou, C.; Geng, P.; Mao, H.; Fang, X. A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma. Int. J. Clin. Exp. Pathol. 2014, 7, 2838–2849. [Google Scholar] [PubMed]
- Xu, Y.Z.; Chen, F.F.; Zhang, Y.; Zhao, Q.F.; Guan, X.L.; Wang, H.Y.; Li, A.; Lv, X.; Song, S.S.; Zhou, Y.; et al. The long noncoding RNA FOXCUT promotes proliferation and migration by targeting FOXC1 in nasopharyngeal carcinoma. Tumour Biol. 2017, 39. [Google Scholar] [CrossRef] [Green Version]
- Hanahan, D.; Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86, 353–364. [Google Scholar] [CrossRef] [Green Version]
- Adamo, P.; Ladomery, M.R. The oncogene ERG: A key factor in prostate cancer. Oncogene 2016, 35, 403–414. [Google Scholar] [CrossRef]
- Li, D.; Chen, Y.; Mei, H.; Jiao, W.; Song, H.; Ye, L.; Fang, E.; Wang, X.; Yang, F.; Huang, K.; et al. Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression. Oncogene 2018, 37, 4871–4886. [Google Scholar] [CrossRef] [Green Version]
- Shav-Tal, Y.; Zipori, D. PSF and p54(nrb)/NonO--multi-functional nuclear proteins. FEBS Lett. 2002, 531, 109–114. [Google Scholar] [CrossRef] [Green Version]
- Lambert, A.W.; Pattabiraman, D.R.; Weinberg, R.A. Emerging Biological Principles of Metastasis. Cell 2017, 168, 670–691. [Google Scholar] [CrossRef] [Green Version]
- Nieto, M.A.; Huang, R.Y.; Jackson, R.A.; Thiery, J.P. EMT: 2016. Cell 2016, 166, 21–45. [Google Scholar] [CrossRef] [Green Version]
- Sánchez-Tilló, E.; Liu, Y.; de Barrios, O.; Siles, L.; Fanlo, L.; Cuatrecasas, M.; Darling, D.S.; Dean, D.C.; Castells, A.; Postigo, A. EMT-activating transcription factors in cancer: Beyond EMT and tumor invasiveness. Cell. Mol. Life Sci. 2012, 69, 3429–3456. [Google Scholar] [CrossRef]
- Boque-Sastre, R.; Soler, M.; Oliveira-Mateos, C.; Portela, A.; Moutinho, C.; Sayols, S.; Villanueva, A.; Esteller, M.; Guil, S. Head-to-head antisense transcription and R-loop formation promotes transcriptional activation. Proc. Natl. Acad. Sci. USA 2015, 112, 5785–5790. [Google Scholar] [CrossRef] [Green Version]
- Li, D.; Wang, X.; Mei, H.; Fang, E.; Ye, L.; Song, H.; Yang, F.; Li, H.; Huang, K.; Zheng, L.; et al. Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization. Cancer Res. 2018, 78, 1169–1183. [Google Scholar] [CrossRef] [Green Version]
- Wang, Y.; Yao, J.; Meng, H.; Yu, Z.; Wang, Z.; Yuan, X.; Chen, H.; Wang, A. A novel long non-coding RNA, hypoxia-inducible factor-2α promoter upstream transcript, functions as an inhibitor of osteosarcoma stem cells in vitro. Mol. Med. Rep. 2015, 11, 2534–2540. [Google Scholar] [CrossRef] [Green Version]
- Pisignano, G.; Napoli, S.; Magistri, M.; Mapelli, S.N.; Pastori, C.; Di Marco, S.; Civenni, G.; Albino, D.; Enriquez, C.; Allegrini, S.; et al. A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers. Nat. Commun. 2017, 8, 1–16. [Google Scholar] [CrossRef] [Green Version]
- Magnani, E.; Macchi, F.; Mancini, M.; Lomazzi, V.; Cogliati, S.; Pistore, C.; Mandruzzato, M.; Dock-Bregeon, A.C.; Bonapace, I.M. UHRF1 regulates CDH1 via promoter associated non-coding RNAs in prostate cancer cells. Biochim. Biophys. Acta Gene. Regul. Mech. 2018, 1861, 258–270. [Google Scholar] [CrossRef]
- Mapelli, S.N.; Napoli, S.; Pisignano, G.; Garcia-Escudero, R.; Carbone, G.M.; Catapano, C.V. Deciphering the complexity of human non-coding promoter-proximal transcriptome. Bioinformatics 2019, 35, 2529–2534. [Google Scholar] [CrossRef]
- Heintzman, N.D.; Stuart, R.K.; Hon, G.; Fu, Y.; Ching, C.W.; Hawkins, R.D.; Barrera, L.O.; Van Calcar, S.; Qu, C.; Ching, K.A.; et al. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 2007, 39, 311–318. [Google Scholar] [CrossRef]
- Paronetto, M.P. Ewing sarcoma protein: A key player in human cancer. Int. J. Cell. Biol. 2013, 2013, 642853. [Google Scholar] [CrossRef]
- Scotlandi, K.; Picci, P. Targeting insulin-like growth factor 1 receptor in sarcomas. Curr. Opin. Oncol. 2008, 20, 419–427. [Google Scholar] [CrossRef]
- Paronetto, M.P.; Venables, J.P.; Elliott, D.J.; Geremia, R.; Rossi, P.; Sette, C. Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68. Oncogene 2003, 22, 8707–8715. [Google Scholar] [CrossRef] [Green Version]
- Bomsztyk, K.; Denisenko, O.; Ostrowski, J. hnRNP K: One protein multiple processes. Bioessays 2004, 26, 629–638. [Google Scholar] [CrossRef]
- Pardini, B.; Sabo, A.A.; Birolo, G.; Calin, G.A. Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies. Cancers 2019, 11, 1170. [Google Scholar] [CrossRef] [Green Version]
- Levin, A.A. Treating Disease at the RNA Level with Oligonucleotides. N. Engl. J. Med. 2019, 380, 57–70. [Google Scholar] [CrossRef]
- Civenni, G. Targeting Promoter-Associated Noncoding RNA In Vivo. Methods Mol. Biol. 2017, 1543, 259–270. [Google Scholar] [CrossRef]
- Blank-Giwojna, A.; Postepska-Igielska, A.; Grummt, I. lncRNA KHPS1 Activates a Poised Enhancer by Triplex-Dependent Recruitment of Epigenomic Regulators. Cell Rep. 2019, 26, 2904–2915. [Google Scholar] [CrossRef] [Green Version]
- Ting, A.H.; Schuebel, K.E.; Herman, J.G.; Baylin, S.B. Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat. Genet. 2005, 37, 906–910. [Google Scholar] [CrossRef] [Green Version]
- Castanotto, D.; Tommasi, S.; Li, M.; Li, H.; Yanow, S.; Pfeifer, G.P.; Rossi, J.J. Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol. Ther. 2005, 12, 179–183. [Google Scholar] [CrossRef]
- Chen, Z.; Place, R.F.; Jia, Z.J.; Pookot, D.; Dahiya, R.; Li, L.C. Antitumor effect of dsRNA-induced p21(WAF1/CIP1) gene activation in human bladder cancer cells. Mol. Cancer Ther. 2008, 7, 698–703. [Google Scholar] [CrossRef] [Green Version]
- Li, L.C.; Okino, S.T.; Zhao, H.; Pookot, D.; Place, R.F.; Urakami, S.; Enokida, H.; Dahiya, R. Small dsRNAs induce transcriptional activation in human cells. Proc. Natl. Acad. Sci. USA 2006, 103, 17337–17342. [Google Scholar] [CrossRef] [Green Version]
- Janowski, B.A.; Younger, S.T.; Hardy, D.B.; Ram, R.; Huffman, K.E.; Corey, D.R. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat. Chem. Biol. 2007, 3, 166–173. [Google Scholar] [CrossRef]
- Hu, J.; Chen, Z.; Xia, D.; Wu, J.; Xu, H.; Ye, Z.Q. Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation. Biochem. J. 2012, 447, 407–416. [Google Scholar] [CrossRef] [Green Version]
- Junxia, W.; Ping, G.; Yuan, H.; Lijun, Z.; Jihong, R.; Fang, L.; Min, L.; Xi, W.; Ting, H.; Ke, D.; et al. Double strand RNA-guided endogeneous E-cadherin up-regulation induces the apoptosis and inhibits proliferation of breast carcinoma cells in vitro and in vivo. Cancer Sci. 2010, 101, 1790–1796. [Google Scholar] [CrossRef]
- Kang, M.R.; Yang, G.; Place, R.F.; Charisse, K.; Epstein-Barash, H.; Manoharan, M.; Li, L.C. Intravesical delivery of small activating RNA formulated into lipid nanoparticles inhibits orthotopic bladder tumor growth. Cancer Res. 2012, 72, 5069–5079. [Google Scholar] [CrossRef] [Green Version]
- Wei, J.; Zhao, J.; Long, M.; Han, Y.; Wang, X.; Lin, F.; Ren, J.; He, T.; Zhang, H. p21WAF1/CIP1 gene transcriptional activation exerts cell growth inhibition and enhances chemosensitivity to cisplatin in lung carcinoma cell. BMC Cancer 2010, 10, 1–8. [Google Scholar] [CrossRef] [Green Version]
- Ledford, H. Gene-silencing technology gets first drug approval after 20-year wait. Nature 2018, 560, 291–292. [Google Scholar] [CrossRef]
- Wood, H. FDA approves patisiran to treat hereditary transthyretin amyloidosis. Nat. Rev. Neurol. 2018, 14, 570. [Google Scholar] [CrossRef]
- Jiang, K. Biotech comes to its ‘antisenses’ after hard-won drug approval. Nat. Med. 2013, 19, 252. [Google Scholar] [CrossRef]
- Ottesen, E.W. ISS-N1 makes the First FDA-approved Drug for Spinal Muscular Atrophy. Transl. Neurosci. 2017, 8, 1–6. [Google Scholar] [CrossRef]
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Mercatelli, N.; Palombo, R.; Paronetto, M.P. Emerging Contribution of PancRNAs in Cancer. Cancers 2020, 12, 2035. https://doi.org/10.3390/cancers12082035
Mercatelli N, Palombo R, Paronetto MP. Emerging Contribution of PancRNAs in Cancer. Cancers. 2020; 12(8):2035. https://doi.org/10.3390/cancers12082035
Chicago/Turabian StyleMercatelli, Neri, Ramona Palombo, and Maria Paola Paronetto. 2020. "Emerging Contribution of PancRNAs in Cancer" Cancers 12, no. 8: 2035. https://doi.org/10.3390/cancers12082035
APA StyleMercatelli, N., Palombo, R., & Paronetto, M. P. (2020). Emerging Contribution of PancRNAs in Cancer. Cancers, 12(8), 2035. https://doi.org/10.3390/cancers12082035