Next Article in Journal
Telomerase and CD4 T Cell Immunity in Cancer
Next Article in Special Issue
Lifestyle Intervention on Body Weight and Physical Activity in Patients with Breast Cancer Can Reduce the Risk of Death in Obese Women: The EMILI Study
Previous Article in Journal
A Clinically Applicable Approach to the Classification of B-Cell Non-Hodgkin Lymphomas with Flow Cytometry and Machine Learning
Previous Article in Special Issue
Obesity and the Impact on Cutaneous Melanoma: Friend or Foe?
Open AccessReview

Obesity and Breast Cancer: A Case of Inflamed Adipose Tissue

by Ryan Kolb 1,2,* and Weizhou Zhang 1,2
1
Department of Pathology, Immunology and Laboratory Medicine, Gainesville, FL 32610, USA
2
University of Florida Health Cancer Center, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(6), 1686; https://doi.org/10.3390/cancers12061686
Received: 30 April 2020 / Revised: 9 June 2020 / Accepted: 22 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue How Does Obesity Cause Cancer?)
Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in postmenopausal women and a worse prognosis for all major breast cancer subtypes regardless of menopausal status. While the link between obesity and the pathogenesis of breast cancer is clear, the molecular mechanism of this association is not completely understood due to the complexity of both obesity and breast cancer. The aim of this review is to highlight the association between obesity and breast cancer and discuss the literature, which indicates that this association is due to chronic adipose tissue inflammation. We will discuss the epidemiological data for the association between breast cancer incidence and progression as well as the potential molecular mechanisms for this association. We will focus on the role of inflammation within the adipose tissue during the pathogenesis of breast cancer. A better understanding of how obesity and adipose tissue inflammation affects the pathogenesis of breast cancer will lead to new strategies to reduce breast cancer risk and improve patient outcomes for obese patients. View Full-Text
Keywords: obesity; breast cancer; inflammation obesity; breast cancer; inflammation
Show Figures

Figure 1

MDPI and ACS Style

Kolb, R.; Zhang, W. Obesity and Breast Cancer: A Case of Inflamed Adipose Tissue. Cancers 2020, 12, 1686.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop