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Open AccessReview

A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles

1
Department for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland
2
Department of Urology, Inselspital, Bern University Hospital, 3010 Bern, Switzerland
3
Department of Urology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
4
Biotheranostics, Inc., San Diego, CA 92121, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Cancers 2020, 12(6), 1480; https://doi.org/10.3390/cancers12061480
Received: 12 May 2020 / Revised: 1 June 2020 / Accepted: 2 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue Antigens and Cancer Therapy)
Cripto is a small glycosylphosphatidylinisitol (GPI)-anchored and secreted oncofetal protein that plays important roles in regulating normal physiological processes, including stem cell differentiation, embryonal development, and tissue growth and remodeling, as well as pathological processes such as tumor initiation and progression. Cripto functions as a co-receptor for TGF-β ligands such as Nodal, GDF1, and GDF3. Soluble and secreted forms of Cripto also exhibit growth factor-like activity and activate SRC/MAPK/PI3K/AKT pathways. Glucose-Regulated Protein 78 kDa (GRP78) binds Cripto at the cell surface and has been shown to be required for Cripto signaling via both TGF-β and SRC/MAPK/PI3K/AKT pathways. To provide a comprehensive overview of the scientific literature related to Cripto, we performed, for the first time, a bibliometric analysis of the biological roles of Cripto as reported in the scientific literature covering the last 10 years. We present different fields of knowledge in comprehensive areas of research on Cripto, ranging from basic to translational research, using a keyword-driven approach. Our ultimate aim is to aid the scientific community in conducting targeted research by identifying areas where research has been conducted so far and, perhaps more importantly, where critical knowledge is still missing. View Full-Text
Keywords: CRIPTO; TDGF-1; bibliometric analysis; cancer; development; biochemistry and molecular biology; experimental medical research CRIPTO; TDGF-1; bibliometric analysis; cancer; development; biochemistry and molecular biology; experimental medical research
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MDPI and ACS Style

Rodrigues Sousa, E.; Zoni, E.; Karkampouna, S.; La Manna, F.; Gray, P.C.; De Menna, M.; Kruithof-de Julio, M. A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles. Cancers 2020, 12, 1480. https://doi.org/10.3390/cancers12061480

AMA Style

Rodrigues Sousa E, Zoni E, Karkampouna S, La Manna F, Gray PC, De Menna M, Kruithof-de Julio M. A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles. Cancers. 2020; 12(6):1480. https://doi.org/10.3390/cancers12061480

Chicago/Turabian Style

Rodrigues Sousa, Elisa; Zoni, Eugenio; Karkampouna, Sofia; La Manna, Federico; Gray, Peter C.; De Menna, Marta; Kruithof-de Julio, Marianna. 2020. "A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its Biological Roles" Cancers 12, no. 6: 1480. https://doi.org/10.3390/cancers12061480

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