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Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer

1
Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry ‘Scuola Medica Salernitana’, University of Salerno, 84081 Baronissi, Italy
2
Genomix4Life, via S. Allende 43/L, 84081 Baronissi (SA), Italy
3
CRGS (Genome Research Center for Health), University of Salerno Campus of Medicine, 84081 Baronissi (SA), Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(6), 1477; https://doi.org/10.3390/cancers12061477
Received: 10 May 2020 / Revised: 1 June 2020 / Accepted: 3 June 2020 / Published: 5 June 2020
Estrogen receptors (ERα and ERβ) are ligand-activated transcription factors that play different roles in gene regulation and show both overlapping and specific tissue distribution patterns. ERβ, contrary to the oncogenic ERα, has been shown to act as an oncosuppressor in several instances. However, while the tumor-promoting actions of ERα are well-known, the exact role of ERβ in carcinogenesis and tumor progression is not yet fully understood. Indeed, to date, highly variable and even opposite effects have been ascribed to ERβ in cancer, including for example both proliferative and growth-inhibitory actions. Recently ERβ has been proposed as a potential target for cancer therapy, since it is expressed in a variety of breast cancers (BCs), including triple-negative ones (TNBCs). Because of the dependence of TNBCs on active cellular signaling, numerous studies have attempted to unravel the mechanism(s) behind ERβ-regulated gene expression programs but the scenario has not been fully revealed. We comprehensively reviewed the current state of knowledge concerning ERβ role in TNBC biology, focusing on the different signaling pathways and cellular processes regulated by this transcription factor, as they could be useful in identifying new diagnostic and therapeutic approaches for TNBC. View Full-Text
Keywords: estrogen receptor β; TNBC; cancer cell metabolism; oncosuppressor estrogen receptor β; TNBC; cancer cell metabolism; oncosuppressor
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MDPI and ACS Style

Sellitto, A.; D’Agostino, Y.; Alexandrova, E.; Lamberti, J.; Pecoraro, G.; Memoli, D.; Rocco, D.; Coviello, E.; Giurato, G.; Nassa, G.; Tarallo, R.; Weisz, A.; Rizzo, F. Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer. Cancers 2020, 12, 1477. https://doi.org/10.3390/cancers12061477

AMA Style

Sellitto A, D’Agostino Y, Alexandrova E, Lamberti J, Pecoraro G, Memoli D, Rocco D, Coviello E, Giurato G, Nassa G, Tarallo R, Weisz A, Rizzo F. Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer. Cancers. 2020; 12(6):1477. https://doi.org/10.3390/cancers12061477

Chicago/Turabian Style

Sellitto, Assunta, Ylenia D’Agostino, Elena Alexandrova, Jessica Lamberti, Giovanni Pecoraro, Domenico Memoli, Domenico Rocco, Elena Coviello, Giorgio Giurato, Giovanni Nassa, Roberta Tarallo, Alessandro Weisz, and Francesca Rizzo. 2020. "Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer" Cancers 12, no. 6: 1477. https://doi.org/10.3390/cancers12061477

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