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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

Laboratory of Molecular Disease and Cell Regulation, Department of Biochemistry, School of Medicine, Gachon University, Incheon 406-840, Korea
Cancers 2020, 12(5), 1339; https://doi.org/10.3390/cancers12051339
Received: 28 April 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue The Role of Src Kinase Family in Cancer)
Src family kinases (SFKs) are non-receptor kinases that play a critical role in the pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are upregulated in patients with CRC. Activation of SFKs promotes CRC cell proliferation, metastases to other organs and chemoresistance, as well as the formation of cancer stem cells (CSCs). The enhanced expression level of Src is associated with decreased survival in patients with CRC. Src-mediated regulation of CRC progression involves various membrane receptors, modulators, and suppressors, which regulate Src activation and its downstream targets through various mechanisms. This review provides an overview of the current understanding of the correlations between Src and CRC progression, with a special focus on cancer cell proliferation, invasion, metastasis and chemoresistance, and formation of CSCs. Additionally, this review discusses preclinical and clinical strategies to improve the therapeutic efficacy of drugs targeting Src for treating patients with CRC. View Full-Text
Keywords: Src family kinases; colorectal cancer; metastasis; epithelial–mesenchymal transition; cancer stem cells; drug targeting Src family kinases; colorectal cancer; metastasis; epithelial–mesenchymal transition; cancer stem cells; drug targeting
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Jin, W. Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications. Cancers 2020, 12, 1339.

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