Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis
Institut für Virologie, Zentrum für Infektionsmedizin, Freie Universität Berlin, Robert-von-Ostertag-Straße 7-13, 14163 Berlin, Germany
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Cancers 2020, 12(3), 647; https://doi.org/10.3390/cancers12030647
Received: 22 February 2020 / Revised: 6 March 2020 / Accepted: 7 March 2020 / Published: 10 March 2020
(This article belongs to the Special Issue Bioinformatics Applications in Virally Driven Cancers)
Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research.
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Keywords:
lymphoma; avian cancer; herpesvirus; Marek’s disease virus; vaccine; life cycle; cell tropism
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MDPI and ACS Style
Bertzbach, L.D.; Conradie, A.M.; You, Y.; Kaufer, B.B. Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis. Cancers 2020, 12, 647.
AMA Style
Bertzbach LD, Conradie AM, You Y, Kaufer BB. Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis. Cancers. 2020; 12(3):647.
Chicago/Turabian StyleBertzbach, Luca D.; Conradie, Andelé M.; You, Yu; Kaufer, Benedikt B. 2020. "Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis" Cancers 12, no. 3: 647.
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