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Open AccessReview

MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells

1
Department of Anatomy, School of Medicine, China Medical University, Taichung 404, Taiwan
2
School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
3
Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
4
Research Unit of Non-Coding RNAs and Genome Editing, Division of Clinical Oncology, Department of Medicine, Comprehensive Cancer Center Graz, Medical University of Graz, 8036 Graz, Austria
5
Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(2), 340; https://doi.org/10.3390/cancers12020340
Received: 17 January 2020 / Revised: 30 January 2020 / Accepted: 31 January 2020 / Published: 3 February 2020
Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future. View Full-Text
Keywords: head and neck squamous cell carcinoma; oral cancer; cancer stem cells; non-coding RNAs head and neck squamous cell carcinoma; oral cancer; cancer stem cells; non-coding RNAs
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MDPI and ACS Style

Hsieh, P.-L.; Liao, Y.-W.; Pichler, M.; Yu, C.-C. MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells. Cancers 2020, 12, 340. https://doi.org/10.3390/cancers12020340

AMA Style

Hsieh P-L, Liao Y-W, Pichler M, Yu C-C. MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells. Cancers. 2020; 12(2):340. https://doi.org/10.3390/cancers12020340

Chicago/Turabian Style

Hsieh, Pei-Ling; Liao, Yi-Wen; Pichler, Martin; Yu, Cheng-Chia. 2020. "MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells" Cancers 12, no. 2: 340. https://doi.org/10.3390/cancers12020340

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