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Genetically Engineered Mouse Models for Liver Cancer
Open AccessReview

Animal Modeling of Pediatric Liver Cancer

Divisions of Pediatric Surgery and Surgical Research, Michael E. DeBakey Department of Surgery, Pediatric Surgical Oncology Laboratory, Texas Children’s Surgical Oncology Program, Texas Children’s Liver Tumor Program, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
Author to whom correspondence should be addressed.
Cancers 2020, 12(2), 273; (registering DOI)
Received: 23 December 2019 / Revised: 19 January 2020 / Accepted: 19 January 2020 / Published: 22 January 2020
(This article belongs to the Special Issue Models of Experimental Liver Cancer)
Hepatoblastoma (HB) is the most common pediatric liver malignancy. Management of HB requires multidisciplinary efforts. The 5-year overall survival of this disease is about 80% in developed countries. Despite advances in the care of these patients, survival in recurrent or treatment-refractory disease is lower than 50%. This is due to more complex tumor biology, including hepatocellular carcinoma (HCC)-like mutations and expression of aggressive gene signatures leading to chemoresistance, vascular invasion, and metastatic spread. The current treatment protocols for pediatric liver cancer do not incorporate targeted therapies, and the ability to test these therapies is limited due to the inaccessibility of cell lines and mouse models. In this review, we discuss the current status of preclinical animal modeling in pediatric liver cancer, primarily HB. Although HB is a rare cancer, the research community has worked together to develop a range of interesting and relevant mouse models for diverse preclinical studies. View Full-Text
Keywords: hepatoblastoma; children; mouse model; xenograft; patient-derived xenograft hepatoblastoma; children; mouse model; xenograft; patient-derived xenograft
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Whitlock, R.S.; Yang, T.; Vasudevan, S.A.; Woodfield, S.E. Animal Modeling of Pediatric Liver Cancer. Cancers 2020, 12, 273.

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