Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer
Abstract
:Simple Summary
Abstract
1. Introduction
2. Signaling in the Intestinal Crypt and lncRNAs
2.1. Wnt Signaling
2.2. Notch Signaling
2.3. The Hippo Pathway
2.4. EGF Signaling
2.5. EphB Signaling
2.6. BMP and TGF-β Signaling
3. LncRNA-Directed Therapeutic Approaches
3.1. RNAi
3.2. Antisense Oligonucleotides (ASOs)
3.3. CRISPR Technology
4. Conclusions
Funding
Conflicts of Interest
References
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LncRNA | Phenotype | Signaling Pathway | Mechanism | References |
---|---|---|---|---|
lncGata6 | Stem cells, Tumorigenesis | Wnt | Enhances WNT activity | [57] |
CCAL | Proliferation, Invasion, Migration | Wnt | Stabilizes β-Catenin/TCF-4 complex by suppression of AP-2alpha | [58] |
BCAR4 | Proliferation, Migration | Wnt | Stabilization of β-Catenin | [59] |
CYTOR | Proliferation, EMT | Wnt | Stabilization of β-Catenin | [60] |
MYC locus (CCAT1, CCAT1-L, CCAT2) | Proliferation, Metastasis, Chromosomal instability | Wnt | Regulation of c-MYC expression | [64,65,66,67,68,69,70,71] |
GLCC1 | Proliferation, Survival, Glycolysis | Wnt | Stabilization of c-Myc protein | [72] |
MYU | Cell cycle, Proliferation | Wnt | Interacts with hnRNP-K and stabilizes CDK6 mRNA | [73] |
FOXD2-AS1 | Proliferation, Invasion, Migration | Notch | Regulation of EMT and Notch signaling | [84] |
FAM83H-AS1 | Proliferation, Migration | Notch | Modulates Notch signaling | [88,89] |
LINC00152 | Cell motility, Migration | Hippo | miRNA sponging | [97] |
MALAT1 | Survival, Migration, EMT | Hippo | miRNA sponging; Epigenetic silencing of targets | [94,99] |
TINCR | Proliferation, Metastasis formation | EGF | miRNA sponging | [112] |
CRNDE | Warburg effect, Proliferation | EGF | Activates RAS\MAPK pathway; Interacts with hnRNPUL2 | [115,116] |
HOXA5 | Proliferation | EGF | Modulates EGF signaling | [117] |
CASC9 | Anti-apoptotic, Proliferation | BMP/TGF-β | Interacts with endonuclease CPSF3 | [145] |
TUG1 | EMT, Metastasis formation | BMP/TGF-β | Regulates expression of Vimentin and TWIST1 | [149] |
linc-POU3F3 | Survival, Proliferation, Migration | BMP/TGF-β | Regulates EMT-associated genes, Inhibits BMP signaling | [152] |
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Schwarzmueller, L.; Bril, O.; Vermeulen, L.; Léveillé, N. Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer. Cancers 2020, 12, 3843. https://doi.org/10.3390/cancers12123843
Schwarzmueller L, Bril O, Vermeulen L, Léveillé N. Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer. Cancers. 2020; 12(12):3843. https://doi.org/10.3390/cancers12123843
Chicago/Turabian StyleSchwarzmueller, Laura, Oscar Bril, Louis Vermeulen, and Nicolas Léveillé. 2020. "Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer" Cancers 12, no. 12: 3843. https://doi.org/10.3390/cancers12123843