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Review

Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer

1
Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology and Metabolism, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2
Oncode Institute, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Cancers 2020, 12(12), 3843; https://doi.org/10.3390/cancers12123843
Received: 29 November 2020 / Revised: 15 December 2020 / Accepted: 16 December 2020 / Published: 19 December 2020
(This article belongs to the Special Issue Stemness and Differentiation in Cancer)
Homeostasis of the intestine is maintained by a delicate balance of signaling networks that regulate self-renewal and differentiation. In the past years, increasing evidence suggests that long non-coding RNAs (lncRNAs) are involved in the control of intestinal crypt turnover. Indeed, their deregulation can enable and drive malignant cell growth. Notably, lncRNAs have high tissue specificity, and therefore hold great potential for therapeutic intervention. Here, we address the function of lncRNAs in the intestine in physiological and pathological conditions and discuss promising interference systems to target oncogenic lncRNAs.
Maintenance of the intestinal epithelium is dependent on the control of stem cell (SC) proliferation and differentiation. The fine regulation of these cellular processes requires a complex dynamic interplay between several signaling pathways, including Wnt, Notch, Hippo, EGF, Ephrin, and BMP/TGF-β. During the initiation and progression of colorectal cancer (CRC), key events, such as oncogenic mutations, influence these signaling pathways, and tilt the homeostatic balance towards proliferation and dedifferentiation. Therapeutic strategies to specifically target these deregulated signaling pathways are of particular interest. However, systemic blocking or activation of these pathways poses major risks for normal stem cell function and tissue homeostasis. Interestingly, long non-coding RNAs (lncRNAs) have recently emerged as potent regulators of key cellular processes often deregulated in cancer. Because of their exceptional tissue and tumor specificity, these regulatory RNAs represent attractive targets for cancer therapy. Here, we discuss how lncRNAs participate in the maintenance of intestinal homeostasis and how they can contribute to the deregulation of each signaling pathway in CRC. Finally, we describe currently available molecular tools to develop lncRNA-targeted cancer therapies. View Full-Text
Keywords: colorectal cancer; lncRNAs; RNA-based therapeutics colorectal cancer; lncRNAs; RNA-based therapeutics
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MDPI and ACS Style

Schwarzmueller, L.; Bril, O.; Vermeulen, L.; Léveillé, N. Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer. Cancers 2020, 12, 3843. https://doi.org/10.3390/cancers12123843

AMA Style

Schwarzmueller L, Bril O, Vermeulen L, Léveillé N. Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer. Cancers. 2020; 12(12):3843. https://doi.org/10.3390/cancers12123843

Chicago/Turabian Style

Schwarzmueller, Laura, Oscar Bril, Louis Vermeulen, and Nicolas Léveillé. 2020. "Emerging Role and Therapeutic Potential of lncRNAs in Colorectal Cancer" Cancers 12, no. 12: 3843. https://doi.org/10.3390/cancers12123843

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