Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Study Population
4.2. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Items | Total | No Dysplasia | Metachronous ESCN | p Values |
---|---|---|---|---|
(n = 175) | (n = 155) | (n = 20) | ||
No. (%) | No. (%) | No. (%) | ||
Age (years) | 55.21 ± 9.43 | 55.19 ± 9.45 | 55.40 ± 9.49 | 0.92 |
Cigarette smoking | 0.66 | |||
No | 25 (14.29%) | 21 (13.55%) | 4 (20.00%) | |
Yes (Former/Current) | 150 (85.71%) | 134 (86.45%) | 16 (80.00%) | |
Betel nut chewing | 0.87 | |||
No | 33 (18.86%) | 30 (19.35%) | 3 (15.00%) | |
Yes (Former/Current) | 142 (81.14%) | 125 (80.65%) | 17 (85.00%) | |
Alcohol drinking | 0.47 | |||
No | 42 (24.00%) | 39 (25.16%) | 3 (15.00%) | |
Yes (Former/Current) | 133 (76.00%) | 116 (74.84%) | 17 (85.00%) | |
Alcohol flush | 0.77 | |||
No | 64 (36.57%) | 58 (37.42%) | 6 (30.00%) | |
Yes | 108 (61.71%) | 95 (61.29%) | 13 (65.00%) | |
Missing | 3 (1.71%) | 2 (1.29%) | 1 (5.00%) | |
Stage | 0.53 | |||
I | 35 (20.00%) | 31 (20.00%) | 4 (20.00%) | |
II | 22 (12.57%) | 21 (13.55%) | 1 (5.00%) | |
III | 36 (20.57%) | 33 (21.29%) | 3 (15.00%) | |
IV | 82 (46.86%) | 70 (45.16%) | 12 (60.00%) | |
Location | 0.15 | |||
Oral | 115 (65.71%) | 106 (68.39%) | 9 (45.00%) | |
Pharyngeal | 32 (18.29%) | 26 (16.77%) | 6 (30.00%) | |
Hypopharyngeal | 25 (14.29%) | 20 (12.90%) | 5 (25.00%) | |
Laryngeal | 3 (1.71%) | 3 (1.94%) | (0.00%) | |
LVL classification | 0.001 | |||
A + B | 134 (76.57%) | 125 (80.65%) | 9 (45.00%) | |
C + D | 41 (23.43%) | 30 (19.35%) | 11 (55.00%) |
Items | Total | No Dysplasia | Metachronous ESCN | Logistic Regression | ||
---|---|---|---|---|---|---|
(n = 155) | (n = 20) | |||||
No. (%) | No. (%) | No. (%) | cOR (95% CI) | aOR1 (95% CI) | p Value | |
Cigarette smoking | ||||||
No | 25 (14.29%) | 21 (13.55%) | 4 (20.00%) | 1 | 1 | |
Yes (Former/Current) | 150 (85.71%) | 134 (86.45%) | 16 (80.00%) | 0.63 (0.19, 2.06) | 0.24 (0.05, 1.06) | 0.06 |
Betel nut chewing | ||||||
No | 33 (18.86%) | 30 (19.35%) | 3 (15.00%) | 1 | 1 | |
Yes (Former/Current) | 142 (81.14%) | 125 (80.65%) | 17 (85.00%) | 1.36 (0.37, 4.94) | 1.61 (0.35, 7.42) | 0.54 |
Alcohol drinking | ||||||
No | 42 (24.00%) | 39 (25.16%) | 3 (15.00%) | 1 | 1 | |
Yes (Former/Current) | 133 (76.00%) | 116 (74.84%) | 17 (85.00%) | 1.91 (0.53, 6.85) | 0.98 (0.22, 4.39) | 0.98 |
Alcohol flush | ||||||
No | 64 (36.57%) | 58 (37.42%) | 6 (30.00%) | 1 | 1 | |
Yes | 108 (61.71%) | 95 (61.29%) | 13 (65.00%) | 1.32 (0.48, 3.67) | 1.66 (0.52, 5.27) | 0.39 |
Missing | 3 (1.71%) | 2 (1.29%) | 1 (5.00%) | - | ||
Stage | ||||||
I | 35 (20.00%) | 31 (20.00%) | 4 (20.00%) | 1 | 1 | |
II | 22 (12.57%) | 21 (13.55%) | 1 (5.00%) | 0.37 (0.04, 3.54) | 0.25 (0.02, 3.06) | 0.28 |
III | 36 (20.57%) | 33 (21.29%) | 3 (15.00%) | 0.71 (0.15, 3.40) | 0.38 (0.06, 2.34) | 0.3 |
IV | 82 (46.86%) | 70 (45.16%) | 12 (60.00%) | 1.33 (0.40, 4.45) | 0.81 (0.19, 3.49) | 0.78 |
Location | ||||||
Oral | 115 (65.71%) | 106 (68.39%) | 9 (45.00%) | 1 | 1 | |
Pharyngeal | 32 (18.29%) | 26 (16.77%) | 6 (30.00%) | 2.72 (0.89, 8.32) | 2.25 (0.57, 8.90) | 0.25 |
Hypopharyngeal | 25 (14.29%) | 20 (12.90%) | 5 (25.00%) | 2.94 (0.89, 9.71) | 2.41 (0.54, 10.69) | 0.25 |
Laryngeal | 3 (1.71%) | 3 (1.94%) | 0 (0.00%) | - | - | |
LVL classification | ||||||
A + B | 134 (76.57%) | 125 (80.65%) | 9 (45.00%) | 1 | 1 | |
C + D | 41 (23.43%) | 30 (19.35%) | 11 (55.00%) | 5.09 (1.94, 13.39) | 5.03 (1.52, 16.67) | 0.0083 |
Age (Years) | HNSCC Location | LVL Classification | Metachronous ESCN | Interval (Months) |
---|---|---|---|---|
43 | Oropharynx | A | Low-grade dysplasia | 33 |
57 | Oral cavity | A | Low-grade dysplasia | 10 |
67 | Hypopharynx | A | Low-grade dysplasia | 44 |
51 | Hypopharynx | A | Low-grade dysplasia | 36 |
53 | Oral cavity | B | Low-grade dysplasia | 16 |
80 | Oral cavity | B | Low-grade dysplasia | 26 |
53 | Oral cavity | B | Low-grade dysplasia | 20 |
49 | Hypopharynx | B | Low-grade dysplasia | 22 |
55 | Oral cavity | B | Low-grade dysplasia | 10 |
55 | Oral cavity | C | Low-grade dysplasia | 92 |
56 | Oral cavity | C | Low-grade dysplasia | 73 |
46 | Oropharynx | C | Low-grade dysplasia | 53 |
50 | Oral cavity | C | Low-grade dysplasia | 54 |
63 | Oropharynx | C | Low-grade dysplasia | 11 |
71 | Hypopharynx | C | SCC | 53 |
52 | Hypopharynx | D | Low-grade dysplasia | 53 |
52 | Oropharynx | D | Low-grade dysplasia | 31 |
55 | Oropharynx | D | Low-grade dysplasia | 35 |
39 | Oropharynx | D | SCC | 27 |
61 | Oral cavity | D | SCC | 12 |
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Chen, Y.-H.; Wang, Y.-K.; Chuang, Y.-S.; Hsu, W.-H.; Kuo, C.-H.; Wu, C.-W.; Chan, L.-P.; Wu, M.-T.; Wu, I.-C. Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients. Cancers 2020, 12, 3832. https://doi.org/10.3390/cancers12123832
Chen Y-H, Wang Y-K, Chuang Y-S, Hsu W-H, Kuo C-H, Wu C-W, Chan L-P, Wu M-T, Wu I-C. Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients. Cancers. 2020; 12(12):3832. https://doi.org/10.3390/cancers12123832
Chicago/Turabian StyleChen, Yi-Hsun, Yao-Kuang Wang, Yun-Shiuan Chuang, Wen-Hung Hsu, Chao-Hung Kuo, Che-Wei Wu, Leong-Perng Chan, Ming-Tsang Wu, and I-Chen Wu. 2020. "Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients" Cancers 12, no. 12: 3832. https://doi.org/10.3390/cancers12123832