Premature MicroRNA-Based Therapeutic: A “One-Two Punch” against Cancers
Abstract
:Simple Summary
Abstract
1. Introduction
2. Evolving Knowledge of miRNA Biogenesis
3. Expanding miRNA–RNA Regulatory Networks
4. Regulatory Potential of miRNA* Species
5. Caveat and Opportunity over Premature miRNA Perturbance
6. Functional Annotation of Premature miRNAs in Cancers
6.1. Oncogenic Pre-miRNAs
6.2. Tumor-Suppressive Pre-miRNAs
6.3. Ambivalent Pre-miRNAs
7. The “Ongoing” Premature miRNA Interventions
8. Conclusion and Future Perspective
Author Contributions
Funding
Conflicts of Interest
References
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RNA Species | Decoy RNAs | Target miRNA(s) | Ref. |
---|---|---|---|
Pseudogenes | PTENP1 | miR-20a, miR-19b, miR-21, miR-26a, and miR-214 | [48] |
TUSC2P | miR-17, miR-93, miR-299-3p, miR-520a, miR-608, and miR-661 | [49] | |
LincRNAs | LincRNA-p21 | let-7 | [50] |
Linc-RoR | miR-145-5p, miR-181a-5p, and miR-99b-3p | [51] | |
Linc00673 mutant | miR-1231 | [52] | |
T-UCRs | Uc.160 | miR-155, miR-24 | [53] |
Uc.346A | miR-155 | ||
Uc.348 | miR-29b | ||
Uc.339 | miR-339-3p, miR-663b-3p, and miR-95-5p | [54] | |
CircRNAs | ciRS-7 | miR-7 | [55] |
Sry | miR-138 | ||
CDR1as | miR-7 | [56] |
Annotation | Mature Products | Previous ID | Clustered miRNAs | Type of Cancer | Targets | Biological Implications | Ref. |
---|---|---|---|---|---|---|---|
Oncogenic pre-miRNAs | miR-17-5p/3p | miR-17/miR-17 * | miR-17~92 | Prostate cancer | TIMP3 | Growth↑, invasion↑ | [72] |
Hepatocellular carcinoma | PTEN, GalNT7, VIM | Proliferation↑, migration↑ | [73] | ||||
miR-10b-5p/3p | miR-10b/miR-10b * | _ | Esophageal squamous cell carcinoma | DAZAP1, TSGA10 | Oncogenic autophagy↑, growth↑, metastasis↑ | [74,75] | |
miR-221-5p/3p | miR-221 */miR-221 | miR-222/221 | Prostate cancer | SOCS1, HECTD2, RAB1A | Proliferation↑, migration↑, androgen independent growth↑ | [76,77] | |
Tumor-suppressive pre-miRNAs | miR-126-5p/3p | miR-126 */miR-126 | _ | Breast cancer | CXCL12 | Metastasis↓ | [78] |
miR-144-5p/3p | miR-144 */miR-144 | miR-4732~451a | Lung squamous cell carcinoma | NCS1 | Proliferation↓, invasion↓, migration↓ | [79] | |
miR-524-5p/3p | miR-524 */miR-524 | miR-520b~520d | Glioblastoma | TEAD1, SMAD2, HES1 | Migration↓, proliferation↓ | [80] | |
miR-491-5p/3p | miR-491/- | _ | Glioblastoma | BCL2L1, EGFR, CDK6, IGFBP2 | Proliferation↓, invasion↓, glioma stem cell propagation↓ | [81] | |
Ambivalent pre-miRNAs | miR-31-5p/3p | miR-31/miR-31 * | _ | Oral squamous cell carcinoma | FIH, RHOA | Viability↑, migration↑↓, growth↓ | [82,83] |
miR-9-5p/3p | miR-9/miR-9 * | _ | Breast cancer | CDH1, ITGB1 | Angiogenesis↑, motility↑, invasion↑, drug resistance↓ | [84,85] | |
miR-10b-5p/3p | miR-10b/miR-10b * | _ | Breast cancer | HOXD10, BUB1, PLK1, CCNA2 | Metastasis↑, cell cycle regulation↓, proliferation↓ | [86,87] | |
miR-221-5p/3p | miR-221*/miR-221 | miR-222/221 | Colorectal cancer | MBD2, QKI | Migration↓, motility↓, stemness↑ | [88,89] |
Intervention/Treatment (Company) | Target miRNA | Oligonucleotide Format | Condition(s) or Disease(s) | Stage | Clinical Trials.gov Identifier: | Ref. |
---|---|---|---|---|---|---|
Mature miRNA-based strategies | ||||||
Miravirsen (Santaris Pharma A/S) | miR-122 | Locked Nucleic Acid-modified DNA phosphorothioate antisense oligonucleotide | Hepatitis C | Phase 2a | NCT01200420 | [112] |
MRX34 (Mirna Therapeutics, Inc.) | miR-34a | Liposomal mimic | Primary liver cancer Lymphoma Melanoma Multiple myeloma Renal cell carcinoma Lung cancer | Phase 1 | NCT01829971 | [113] |
TargomiRs (EnGeneIC Limited) | miR-16 | Minicells (EnGeneIC Dream Vectors) loaded with mimic microRNA | Malignant pleural mesothelioma Nonsmall cell lung cancer | Phase 1 | NCT02369198 | [114] |
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Chen, L.; Huang, K.; Yi, K.; Huang, Y.; Tian, X.; Kang, C. Premature MicroRNA-Based Therapeutic: A “One-Two Punch” against Cancers. Cancers 2020, 12, 3831. https://doi.org/10.3390/cancers12123831
Chen L, Huang K, Yi K, Huang Y, Tian X, Kang C. Premature MicroRNA-Based Therapeutic: A “One-Two Punch” against Cancers. Cancers. 2020; 12(12):3831. https://doi.org/10.3390/cancers12123831
Chicago/Turabian StyleChen, Luyue, Kai Huang, Kaikai Yi, Yanlin Huang, Xinhua Tian, and Chunsheng Kang. 2020. "Premature MicroRNA-Based Therapeutic: A “One-Two Punch” against Cancers" Cancers 12, no. 12: 3831. https://doi.org/10.3390/cancers12123831