MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature
Abstract
:Simple Summary
Abstract
1. Introduction
2. Results
2.1. Patient Populations and MR Images
2.2. Imaging Features’ Associations with Diagnosis
2.3. Imaging Features Predicting Retinoblastoma or Pseudoretinoblastoma
2.4. Three Newly Identified MR Imaging Features in Coats’ Disease and PFV/Retinal Dysplasia
2.5. Assessment Strategy for Differentiating Retinoblastoma, Coats’ Disease and PFV/Retinal Dysplasia
3. Discussion
4. Materials and Methods
4.1. Patient Samples
4.2. MR Imaging Assessment
4.3. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Retinoblastoma | Coats’ Disease | PFV/Retinal Dysplasia | |
---|---|---|---|
Patients n (%) | 33 (50%) | 24 (36%) | 9 (14%) (of which n = 2 isolated retinal dysplasia) |
Assessed eyes n (%) | 34 (50%) | 24 (35%) | 10 (15%) |
Laterality OD/OS/ODS | 15/17/1 | 10/14/0 | 3/5/1 |
Stage 1 | B 1/27 (4%) C: 4/27 (15%) D: 7/27 (26%) E: 15/27 (56%) | Advanced stage (3–5): 24/24 (100%) | - |
Female/male (%) | 15/18 (45/55%) | 3/21 (13/88%) | 2/7 (22/78%) |
Mean age at MRI scan in months (standard deviation) | 34 (27) | 38 (30) | 16 (24) |
Mean follow-up duration in months 2 (standard deviation) | 59 (41) | 16 (27) | 13 (16) |
Mean scan year (range) | 2013 (1997–2019) | 2013 (2009–2019) | 2014 (1999–2019) |
Imaging Feature | Retinoblastoma 1 | Coats’ Disease 1 | PFV/ Retinal Dysplasia 1 | Pseudoretinoblastoma (Coats’ Disease and PFV) | K 2 | p3 |
---|---|---|---|---|---|---|
Eye size 4 | 0.37 | <0.001 | ||||
Smaller | 9% (3/33) | 67% (16/24) | 80% (8/10) | 71% (24/34) | ||
Equal | 82% (27/33) | 33% (8/24) | 10% (1/10) | 26% (9/34) | ||
Larger | 9% (3/33) | 0% (0/24) | 10% (1/10) | 3% (1/34) | ||
Ciliary deformations | 0% (0/34) | 13% (3/24) | 78% (7/9) | 30% (10/33) | 0.39 | <0.001 |
Lens deformations | 3% (1/34) | 17% (4/24) | 90% (9/10) | 38% (13/34) | 0.53 | <0.001 |
Optic nerve atrophy | 0% (0/34) | 0% (0/24) | 70% (7/10) | 21% (7/34) | 0.49 | <0.001 |
Central stalk 5 | 0% (0/34) | 4% (1/23) | 70% (7/10) | 24% (8/33) | 0.43 | <0.001 |
Shape of retinal detachment 6 | 0.40 | 0.007 | ||||
T | 22% (7/32) | 25% (5/20) | 44% (4/9) | 31% (9/29) | ||
Y | 0% (0/32) | 20% (4/20) | 44% (4/9) | 28% (8/29) | ||
Sharp-V | 25% (8/32 | 5% (1/20) | 11% (1/9) | 7% (2/29) | ||
Wide-V | 53% (17/32) | 50% (10/20) | 0% (0/9) | 34% (10/29) | ||
Intraretinal macrocyst | 0% (0/34) | 38% (9/24) | 20% (2/10) | 32% (11/34) | 0.55 | 0.005 |
Absence of calcifications | 0% (0/34) | 67% (14/21) | 50% (4/8) | 62% (18/29) | 0.35 | <0.001 |
Lesion islands/seeding | 0.44 | <0.001 | ||||
Vitreous | 30% (10/33) | 4% (1/23) | 0% (0/10) | 3% (1/33) | ||
Subretinal | 64% (21/33) | 30% (7/23) | 10% (1/10) | 24% (8/33) | ||
No/minimal enhancement in solid lesion | 3% (1/34) | 31% (7/22) | 57% (4/7) | 38% (11/29) | 0.35 | 0.008 |
Enhancement outside solid lesion (mismatch) | 0% (0/34) | 30% (7/23) | 57% (4/7) | 37% (11/30) | 0.15 | <0.001 |
Features Favoring | Imaging Feature 1 | Sensitivity (95%CI) | Specificity (95%CI) | Accuracy (95%CI) | |
---|---|---|---|---|---|
Retinoblastoma | Larger eye size 2 | 9% (2–25%) | 97% (85–100%) | 54% (41–66%) | |
Narrow V-shape | 25% (11–43%) | 93% (77–99%) | 57% (44–70%) | ||
Lesion islands/vitreous | 30% (16–49%) | 96% (78–100%) | 58% (44–71%) | ||
Pseudoretinoblastoma | Smaller eye size 1 | 71% (53–85%) | 91% (76–98%) | 81% (69–89%) | |
Y-shaped retinal detachment | 28% (13–47%) | 100% (89–100%) | 65% (52–77%) | ||
Absence of calcifications | 62% (42–79%) | 100% (90–100%) | 83% (81–91%) | ||
Intraretinal macrocysts | 32% (17–51%) | 100% (90–100%) | 66% (54–77%) | ||
No/minimal enhancement in solid lesion | 38% (21–57%) | 97% (85–100%) | 70% (57–81%) | ||
Enhancement outside solid lesion (mismatch) | 37% (20–56%) | 100% (90–100%) | 70% (58–81%) | ||
Ciliary body deformations | 30% (65–93%) | 100% (89–100%) | 66% (53–77%) | ||
Lens deformations | 38% (22–56%) | 97% (84–100%) | 68% (55–78%) | ||
Optic nerve atrophy | 22% (9–40%) | 100% (89–100%) | 62% (49–74%) | ||
Central stalk 3 | 24% (11–42%) | 100% (89–100%) | 63% (50–74%) | ||
Individual pseudoretinoblastoma | PFV/retinal dysplasia | Ciliary body deformations | 78% (40–97%) | 95% (86–99%) | 93% (83–98%) |
Lens deformations | 90% (56–100%) | 91% (81–97%) | 91% (82–97%) | ||
Optic nerve atrophy | 70% (35–93%) | 100% (94–100%) | 96% (88–99%) | ||
Central stalk 2 | 70% (35–93%) | 98% (91–100%) | 94% (85–98%) | ||
Coats’ disease | Intraretinal macrocysts | 38% (19–59%) | 95% (85–99%) | 38% (19–59%) |
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Jansen, R.W.; de Bloeme, C.M.; Brisse, H.J.; Galluzzi, P.; Cardoen, L.; Göricke, S.; Maeder, P.; Cassoux, N.; Gauthier, A.; Schlueter, S.; et al. MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature. Cancers 2020, 12, 3592. https://doi.org/10.3390/cancers12123592
Jansen RW, de Bloeme CM, Brisse HJ, Galluzzi P, Cardoen L, Göricke S, Maeder P, Cassoux N, Gauthier A, Schlueter S, et al. MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature. Cancers. 2020; 12(12):3592. https://doi.org/10.3390/cancers12123592
Chicago/Turabian StyleJansen, Robin W., Christiaan M. de Bloeme, Hervé J. Brisse, Paolo Galluzzi, Liesbeth Cardoen, Sophia Göricke, Philippe Maeder, Nathalie Cassoux, Arnaud Gauthier, Sabrina Schlueter, and et al. 2020. "MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature" Cancers 12, no. 12: 3592. https://doi.org/10.3390/cancers12123592
APA StyleJansen, R. W., de Bloeme, C. M., Brisse, H. J., Galluzzi, P., Cardoen, L., Göricke, S., Maeder, P., Cassoux, N., Gauthier, A., Schlueter, S., Hadjistilianou, T., Munier, F. L., Castelijns, J. A., van der Valk, P., Moll, A. C., de Jong, M. C., & de Graaf, P. (2020). MR Imaging Features to Differentiate Retinoblastoma from Coats’ Disease and Persistent Fetal Vasculature. Cancers, 12(12), 3592. https://doi.org/10.3390/cancers12123592