Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy
Abstract
:Simple Summary
Abstract
1. Introduction
2. External Beam Systems
2.1. Hyperthermia
2.2. Photothermal Therapy
2.3. Magnetic Field
3. Photodynamic Therapy
4. Radiosensitizers
5. Potential Limitations
6. Conclusions
Funding
Conflicts of Interest
Abbreviations
AR | chimeric antigen receptor |
ICD | immunogenic cell death |
DAMPs | damage-associated molecular patterns |
ER | endoplasmic reticulum |
Hsp70 | heat shock protein 70 |
NK | natural killer |
DC | dendritic cell |
HMGB1 | high mobility group box 1 |
TLRs | toll-like receptors |
mtDNA | mitochondrial DNA |
CpG | cytosine-guanine |
IFNs | interferons |
TNFs | tumor necrosis factors |
ILs | interleukins |
NIR | near-infrared |
PTT | photothermal therapy |
IDO | indoleamine 2,3-dioxygenase |
PDT | photodynamic therapy |
MMP2 | matrix metalloproteinase 2 |
ROS | reactive oxygen species |
PEG | polyethylene glycol |
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System | Trigger | Nanoparticle Complexes |
---|---|---|
Hyperthermia | NIR | Melanin [15], graphene oxide with iron oxide [16], IR820 [17], NaGdF4:Yb/Er [20], gold nanoparticles [21,25,26], copper hydroxide [22], black phosphorus [27] |
AMF | Ferrites [19,29,30], pure iron [31] | |
Photodynamic therapy | NIR | Zinc phthalocyanine [33], indocyanine green [34], gold nanoparticle [35], chlorine e6 [20,21,29,38,41,42] |
Radiotherapy | Ionizing Radiation | Hafnium oxide [43,44,45], tungsten [46], bismuth [47] |
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Sahin, O.; Meiyazhagan, A.; Ajayan, P.M.; Krishnan, S. Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy. Cancers 2020, 12, 3559. https://doi.org/10.3390/cancers12123559
Sahin O, Meiyazhagan A, Ajayan PM, Krishnan S. Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy. Cancers. 2020; 12(12):3559. https://doi.org/10.3390/cancers12123559
Chicago/Turabian StyleSahin, Onur, Ashokkumar Meiyazhagan, Pulickel M. Ajayan, and Sunil Krishnan. 2020. "Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy" Cancers 12, no. 12: 3559. https://doi.org/10.3390/cancers12123559