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Review

Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives

1
Ophthalmology Department, University Hospital, Cote d’Azur University of Nice, 06 000 Nice, France
2
CNRS UMR7284, Inserm U1081, Institute for Research on Cancer and Aging Nice (IRCAN), FHU OncoAge, Cote d’Azur University, 06 000 Nice, France
3
Oncology Department, Antoine Lacassagne Cancer Centre, 06 000 Nice, France
4
Centre Méditerranéen de Médecine Moléculaire (C3M), INSERM, Université Nice Côte d’Azur, 06 200 Nice, France
5
Antoine Lacassagne Cancer Center, FHU OncoAge, 06 000 Nice, France
6
Laboratory of Clinical and Experimental Pathology, University Hospital of Nice, FHU OncoAge and Biobank BB-0033-00025, IRCAN, 06 000 Nice, France
7
Laboratory of Clinical and Experimental Pathology, Pasteur 1 Hospital, University Hospital of Nice, 30 voie romaine, 06000 Nice, France
*
Authors to whom correspondence should be addressed.
Cancers 2020, 12(11), 3284; https://doi.org/10.3390/cancers12113284
Received: 4 October 2020 / Revised: 29 October 2020 / Accepted: 3 November 2020 / Published: 6 November 2020
(This article belongs to the Collection Cancer Biomarkers)
To date, there is no treatment for metastatic uveal melanoma. Identifying its metastatic spread is essential. Liquid biopsy can identify patients at risk of metastatic spread early. Here, we aim to summarize the current knowledge of liquid biopsy in ophthalmic malignant tumors, including uveal melanoma. Our objective is to establish the current state of liquid biopsy in the ophthalmic field, as well as its perspectives and limitations.
Tissue biopsy is considered the gold standard when establishing a diagnosis of cancer. However, tissue biopsies of intraocular ophthalmic malignancies are hard to collect and are thought to be associated with a non-negligible risk of extraocular dissemination. Recently, the liquid biopsy (LB) has emerged as a viable, non-invasive, repeatable, and promising way of obtaining a diagnosis, prognosis, and theragnosis of patients with solid tumors. LB refers to blood, as well as any human liquid. The natural history of uveal melanoma (UM) and retinoblastoma (RB) are radically opposed. On the one hand, UM is known to disseminate through the bloodstream, and is, therefore, more accessible to systemic venous liquid biopsy. On the other hand, RB rarely disseminates hematogenous, and is, therefore, more accessible to local liquid biopsy by performing an anterior chamber puncture. In this review, we summarize the current knowledge concerning LB in UM, RB, conjunctival tumors, and choroidal metastases. We also develop the current limitations encountered, as well as the perspectives. View Full-Text
Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; uveal melanoma; retinoblastoma liquid biopsy; circulating tumor cells; circulating tumor DNA; uveal melanoma; retinoblastoma
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MDPI and ACS Style

Martel, A.; Baillif, S.; Nahon-esteve, S.; Gastaud, L.; Bertolotto, C.; Roméo, B.; Mograbi, B.; Lassalle, S.; Hofman, P. Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives. Cancers 2020, 12, 3284. https://doi.org/10.3390/cancers12113284

AMA Style

Martel A, Baillif S, Nahon-esteve S, Gastaud L, Bertolotto C, Roméo B, Mograbi B, Lassalle S, Hofman P. Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives. Cancers. 2020; 12(11):3284. https://doi.org/10.3390/cancers12113284

Chicago/Turabian Style

Martel, Arnaud, Stephanie Baillif, Sacha Nahon-esteve, Lauris Gastaud, Corine Bertolotto, Barnabé Roméo, Baharia Mograbi, Sandra Lassalle, and Paul Hofman. 2020. "Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives" Cancers 12, no. 11: 3284. https://doi.org/10.3390/cancers12113284

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