Next Article in Journal
Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia
Next Article in Special Issue
Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer
Previous Article in Journal
Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4
Previous Article in Special Issue
Roles of NRF3 in the Hallmarks of Cancer: Proteasomal Inactivation of Tumor Suppressors
Open AccessReview

Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases

Department of Oncology, University of Torino, 10060 Candiolo, Italy
Candiolo Cancer Institute-FPO, IRCCS, 10060 Candiolo, Italy
Unit of Oncology and Molecular Pathology, Department of Biomedical Sciences, University of Cagliari, 09042 Monserrato, Italy
Authors to whom correspondence should be addressed.
Cancers 2020, 12(10), 2932;
Received: 9 September 2020 / Revised: 29 September 2020 / Accepted: 8 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue The KEAP1-NRF2 Pathway in Cancer)
Although the Keap1-Nrf2 pathway represents a powerful cell defense mechanism against a variety of toxic insults, its role in acute or chronic liver damage and tumor development is not completely understood. This review addresses how Nrf2 is involved in liver pathophysiology and critically discusses the contrasting results emerging from the literature. The aim of the present report is to stimulate further investigation on the role of Nrf2 that could lead to define the best strategies to therapeutically target this pathway.
Activation of the Keap1/Nrf2 pathway, the most important cell defense signal, triggered to neutralize the harmful effects of electrophilic and oxidative stress, plays a crucial role in cell survival. Therefore, its ability to attenuate acute and chronic liver damage, where oxidative stress represents the key player, is not surprising. On the other hand, while Nrf2 promotes proliferation in cancer cells, its role in non-neoplastic hepatocytes is a matter of debate. Another topic of uncertainty concerns the nature of the mechanisms of Nrf2 activation in hepatocarcinogenesis. Indeed, it remains unclear what is the main mechanism behind the sustained activation of the Keap1/Nrf2 pathway in hepatocarcinogenesis. This raises doubts about the best strategies to therapeutically target this pathway. In this review, we will analyze and discuss our present knowledge concerning the role of Nrf2 in hepatic physiology and pathology, including hepatocellular carcinoma. In particular, we will critically examine and discuss some findings originating from animal models that raise questions that still need to be adequately answered. View Full-Text
Keywords: liver regeneration; acute and chronic liver injury; multistep hepatocarcinogenesis; Keap1/Nrf2 pathway liver regeneration; acute and chronic liver injury; multistep hepatocarcinogenesis; Keap1/Nrf2 pathway
Show Figures

Figure 1

MDPI and ACS Style

Orrù, C.; Giordano, S.; Columbano, A. Nrf2 in Neoplastic and Non-Neoplastic Liver Diseases. Cancers 2020, 12, 2932.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop