Next Article in Journal
Novel Concepts of Treatment for Patients with Myelofibrosis and Related Neoplasms
Next Article in Special Issue
Regulatory Mechanisms of Epigenetic miRNA Relationships in Human Cancer and Potential as Therapeutic Targets
Previous Article in Journal
Aptamers: Novel Therapeutics and Potential Role in Neuro-Oncology
Previous Article in Special Issue
tRNA-Derived Small RNAs: Novel Epigenetic Regulators
Review

Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer

Laboratory of Molecular Oncology, IMDEA-Food Institute, CEI UAM + CSIC, 28049 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cancers 2020, 12(10), 2890; https://doi.org/10.3390/cancers12102890
Received: 4 September 2020 / Revised: 5 October 2020 / Accepted: 7 October 2020 / Published: 9 October 2020
(This article belongs to the Collection Regulatory and Non-Coding RNAs in Cancer Epigenetic Mechanisms)
Reprogramming of energy metabolism is an emerging hallmark of cancer development. Progression in a tumor cell requires new biogenesis of fatty acids (FA) for membrane synthesis, as signaling molecules or as energy input. Here, we provide a review of fatty acid metabolism misbalance from a cancer perspective (lipids’ storage formation, their hydrolysis, extra FAs uptake, FA synthesis, FA oxidation, and finally, FA activation and desaturation) and we summarize the reported non-coding RNAs affecting these processes as new strategies to target fatty acid availability in cancer cells.
Cancer cells commonly display metabolic fluctuations. Together with the Warburg effect and the increased glutaminolysis, alterations in lipid metabolism homeostasis have been recognized as a hallmark of cancer. Highly proliferative cancer cells upregulate de novo synthesis of fatty acids (FAs) which are required to support tumor progression by exerting multiple roles including structural cell membrane composition, regulators of the intracellular redox homeostasis, ATP synthesis, intracellular cell signaling molecules, and extracellular mediators of the tumor microenvironment. Epigenetic modifications have been shown to play a crucial role in human development, but also in the initiation and progression of complex diseases. The study of epigenetic processes could help to design new integral strategies for the prevention and treatment of metabolic disorders including cancer. Herein, we first describe the main altered intracellular fatty acid processes to support cancer initiation and progression. Next, we focus on the most important regulatory and non-coding RNAs (small noncoding RNA—sncRNAs—long non-coding RNAs—lncRNAs—and other regulatory RNAs) which may target the altered fatty acids pathway in cancer. View Full-Text
Keywords: molecular biology; cancer; metabolic reprogramming; fatty acid metabolism; regulatory RNAs; non-coding RNAs molecular biology; cancer; metabolic reprogramming; fatty acid metabolism; regulatory RNAs; non-coding RNAs
Show Figures

Graphical abstract

MDPI and ACS Style

Cruz-Gil, S.; Fernández, L.P.; Sánchez-Martínez, R.; Gómez de Cedrón, M.; Ramírez de Molina, A. Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer. Cancers 2020, 12, 2890. https://doi.org/10.3390/cancers12102890

AMA Style

Cruz-Gil S, Fernández LP, Sánchez-Martínez R, Gómez de Cedrón M, Ramírez de Molina A. Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer. Cancers. 2020; 12(10):2890. https://doi.org/10.3390/cancers12102890

Chicago/Turabian Style

Cruz-Gil, Silvia, Lara P. Fernández, Ruth Sánchez-Martínez, Marta Gómez de Cedrón, and Ana Ramírez de Molina. 2020. "Non-Coding and Regulatory RNAs as Epigenetic Remodelers of Fatty Acid Homeostasis in Cancer" Cancers 12, no. 10: 2890. https://doi.org/10.3390/cancers12102890

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop