Next Article in Journal
Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds
Previous Article in Journal
Prediction of Postoperative Clinical Outcomes in Resected Stage I Non-Small Cell Lung Cancer Focusing on the Preoperative Glasgow Prognostic Score
Open AccessReview

The Regulation of the Metastatic Cascade by Physical Activity: A Narrative Review

Institute of Neuroscience, Université Catholique de Louvain, Place Pierre de Coubertin 1 L08.10.01, 1348 Louvain-la-Neuve, Belgium
Author to whom correspondence should be addressed.
Cancers 2020, 12(1), 153;
Received: 22 November 2019 / Revised: 23 December 2019 / Accepted: 6 January 2020 / Published: 8 January 2020
The purpose of this narrative review is to provide an overview of the currently available knowledge about the mechanisms by which physical activity may affect metastatic development. The search terms exercise [Title/Abstract] AND metastasis [Title/Abstract] returned 222 articles on PUBMED on the 10 February 2019. After careful analysis of the abstracts, a final selection of 24 articles was made. Physical activity regulates the levels of metastatic factors in each of the five steps of the process. Moderate intensity exercise appears to prevent tumor spread around the body, among others, by normalizing angiogenesis, destroying circulating tumor cells, and decreasing endothelial cells permeability. Contrarily, high-intensity exercise seems to favor cancer dissemination, likely through excessive stress, which can be somewhat counteracted by an appropriate warm-up. In conclusion, chronic adaptations to moderate-intensity endurance exercise seem the most effective way to achieve a preventive effect of exercise on metastases. Altogether, the data gathered here reinforce the importance of encouraging cancer patients to perform moderate physical activity several times a week. To limit the undesired events thereof, a good knowledge of the patient’s training level is important to establish an adapted exercise training program. View Full-Text
Keywords: exercise; cancer; tumor; endurance exercise; cancer; tumor; endurance
Show Figures

Graphical abstract

MDPI and ACS Style

van Doorslaer de ten Ryen, S.; Deldicque, L. The Regulation of the Metastatic Cascade by Physical Activity: A Narrative Review. Cancers 2020, 12, 153.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop