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Correction published on 30 November 2020, see Cancers 2020, 12(12), 3587.
Open AccessArticle

Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α

1
Department of Pharmaceutical Sciences, Yarmouk University—Faculty of Pharmacy, Irbid 566, Jordan
2
School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, UK
3
Department of Mathematics and Sciences, College of Arts and Applied Sciences Dhofar University Salalah, Salalah 211, Oman
4
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Tanta, Tanta 31111, Egypt
5
Department of Biological Sciences, Yarmouk University—Faculty of Science, Irbid 566, Jordan
6
Department of Basic Medical Sciences, Yarmouk University—Faculty of Medicine, Irbid 566, Jordan
7
Department of Pharmacy and Biomedical Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK
8
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India
9
Department of Gynecology, European Competence Center for Ovarian Cancer, Campus Virchow, Klinikum Charite-Universitatmedizin Berlin, augustenburger Platz 1, 13353 Berlin, Germany
10
Department of Dermatology, Venerology, and allergology, Charite—Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Chariteplatz1, 10117 Berlin, Germany
11
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India
12
School of Pharmacy, Royal College of Surgeons in Ireland, Dublin-09 D02 YN77, Ireland
13
Department of Forensic Science, School of Applied Science, Huddersfield University, Queensgate, Huddersfield HD1 3DH, UK
14
Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India
15
School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur 302017, India
16
Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 230, Australia
17
Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India
18
Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, Av. Vicuña McKenna 4860, 7820436, Macul, Santiago 4860, Chile
19
School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, India 173229, India
20
Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia
21
School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
22
Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, NSW 2007, Australia
23
Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this study.
Cancers 2020, 12(1), 113; https://doi.org/10.3390/cancers12010113
Received: 12 November 2019 / Revised: 4 December 2019 / Accepted: 12 December 2019 / Published: 1 January 2020
(This article belongs to the Special Issue Targeting Therapy for Colon Cancer)
Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC–BSA nanoparticles (NPs). These PIC–BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1α. Our results indicate that PIC–BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1α in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC–BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC–BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC–BSA NPs, enhances its therapeutic potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possible human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients. View Full-Text
Keywords: piceatannol; colon cancer; albumin nanoparticles; nuclear P65; HIF-1α piceatannol; colon cancer; albumin nanoparticles; nuclear P65; HIF-1α
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Figure 1

MDPI and ACS Style

A. A. Aljabali, A.; A. Bakshi, H.; L. Hakkim, F.; Haggag, Y.A.; M. Al-Batanyeh, K.; S. Al Zoubi, M.; Al-Trad, B.; M. Nasef, M.; Satija, S.; Mehta, M.; Pabreja, K.; Mishra, V.; Khan, M.; Abobaker, S.; M. Azzouz, I.; Dureja, H.; M. Pabari, R.; Ali K. Dardouri, A.; Kesharwani, P.; Gupta, G.; Dhar Shukla, S.; Prasher, P.; B. Charbe, N.; Negi, P.; N. Kapoor, D.; Chellappan, D.K.; Webba da Silva, M.; Thompson, P.; Dua, K.; McCarron, P.; M. Tambuwala, M. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α. Cancers 2020, 12, 113. https://doi.org/10.3390/cancers12010113

AMA Style

A. A. Aljabali A, A. Bakshi H, L. Hakkim F, Haggag YA, M. Al-Batanyeh K, S. Al Zoubi M, Al-Trad B, M. Nasef M, Satija S, Mehta M, Pabreja K, Mishra V, Khan M, Abobaker S, M. Azzouz I, Dureja H, M. Pabari R, Ali K. Dardouri A, Kesharwani P, Gupta G, Dhar Shukla S, Prasher P, B. Charbe N, Negi P, N. Kapoor D, Chellappan DK, Webba da Silva M, Thompson P, Dua K, McCarron P, M. Tambuwala M. Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α. Cancers. 2020; 12(1):113. https://doi.org/10.3390/cancers12010113

Chicago/Turabian Style

A. A. Aljabali, Alaa; A. Bakshi, Hamid; L. Hakkim, Faruck; Haggag, Yusuf A.; M. Al-Batanyeh, Khalid; S. Al Zoubi, Mazhar; Al-Trad, Bahaa; M. Nasef, Mohamed; Satija, Saurabh; Mehta, Meenu; Pabreja, Kavita; Mishra, Vijay; Khan, Mohammed; Abobaker, Salem; M. Azzouz, Ibrahim; Dureja, Harish; M. Pabari, Ritesh; Ali K. Dardouri, Ashref; Kesharwani, Prashant; Gupta, Gaurav; Dhar Shukla, Shakti; Prasher, Parteek; B. Charbe, Nitin; Negi, Poonam; N. Kapoor, Deepak; Chellappan, Dinesh K.; Webba da Silva, Mateus; Thompson, Paul; Dua, Kamal; McCarron, Paul; M. Tambuwala, Murtaza. 2020. "Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α" Cancers 12, no. 1: 113. https://doi.org/10.3390/cancers12010113

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