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Open AccessArticle

Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems

1
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
2
Department of Radiology, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Hwaseong 18450, Korea
3
Department of Pediatric Surgery, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul 05505, Korea
4
Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul 05505, Korea
*
Author to whom correspondence should be addressed.
These authors have equally contributed to this work.
Cancers 2019, 11(9), 1387; https://doi.org/10.3390/cancers11091387
Received: 10 July 2019 / Revised: 11 September 2019 / Accepted: 11 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Hepatoblastoma and Pediatric Liver Tumors)
This study aimed to evaluate the prognostic value of variables used in the 2017 PRE-Treatment EXTent of tumor (PRETEXT) system and the Children’s Hepatic tumors International Collaboration-Hepatoblastoma Stratification (CHIC-HS) system in pediatric patients with hepatoblastoma. A retrospective analysis of data from the pediatric hepatoblastoma registry of a tertiary referral center was conducted to evaluate the clinical and imaging variables (annotation factors) of the PRETEXT staging system. The primary outcome was event-free survival (EFS). Data from 84 patients (mean age: 2.9 ± 3.5 years) identified between 1998 and 2017 were included. Univariable Cox proportional hazards analysis revealed that PRETEXT annotation factors P (portal vein involvement), F (multifocality of tumor), and M (distant metastasis) showed a significant negative association with EFS. Multivariable Cox proportional hazard analysis showed that factor F was the strongest predictor (HR (hazard ratio), 2.908; 95% CI (confidence interval), 1.061–7.972; p = 0.038), whereas factor M showed borderline significance (HR, 2.416; 95% CI, 0.918–6.354; p = 0.074). The prediction model based on F and M (F + M) showed good performance to predict EFS (C-statistic, 0.734; 95% CI, 0.612–0.854). In conclusion, the PRETEXT annotation factor F was the strongest predictor of EFS, and the F + M model showed good performance to predict EFS in pediatric patients with hepatoblastoma. View Full-Text
Keywords: hepatoblastoma; pediatric; prognostic factor; PRETEXT; imaging hepatoblastoma; pediatric; prognostic factor; PRETEXT; imaging
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MDPI and ACS Style

Yoon, H.M.; Hwang, J.; Kim, K.W.; Namgoong, J.-M.; Kim, D.Y.; Koh, K.-N.; Kim, H.; Cho, Y.A. Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems. Cancers 2019, 11, 1387.

AMA Style

Yoon HM, Hwang J, Kim KW, Namgoong J-M, Kim DY, Koh K-N, Kim H, Cho YA. Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems. Cancers. 2019; 11(9):1387.

Chicago/Turabian Style

Yoon, Hee M.; Hwang, Jisun; Kim, Kyung W.; Namgoong, Jung-Man; Kim, Dae Y.; Koh, Kyung-Nam; Kim, Hyery; Cho, Young A. 2019. "Prognostic Factors for Event-Free Survival in Pediatric Patients with Hepatoblastoma Based on the 2017 PRETEXT and CHIC-HS Systems" Cancers 11, no. 9: 1387.

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