EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells
AbstractMetastasis and tumor progression are the major cause of death in patients suffering from pancreatic ductal adenocarcinoma. Tumor growth and especially dissemination are typically associated with activation of an epithelial-to-mesenchymal transition (EMT) program. This phenotypic transition from an epithelial to a mesenchymal state promotes migration and survival both during development and in cancer progression. When re-activated in pathological contexts such as cancer, this type of developmental process confers additional stemness properties to specific subsets of cells. Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem-like features that are responsible for the propagation of the tumor as well as therapy resistance and cancer relapse, but also for circulating tumor cell release and metastasis. In support of this concept, EMT transcription factors generate cells with stem cell properties and mediate chemoresistance. However, their role in pancreatic ductal adenocarcinoma metastasis remains controversial. As such, a better characterization of CSC populations will be crucial in future development of therapies targeting these cells. In this review, we will discuss the latest updates on the mechanisms common to pancreas development and CSC-mediated tumor progression. View Full-Text
Share & Cite This Article
Rodriguez-Aznar, E.; Wiesmüller, L.; Sainz, B., Jr.; Hermann, P.C. EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells. Cancers 2019, 11, 1136.
Rodriguez-Aznar E, Wiesmüller L, Sainz B, Jr, Hermann PC. EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells. Cancers. 2019; 11(8):1136.Chicago/Turabian Style
Rodriguez-Aznar, Eva; Wiesmüller, Lisa; Sainz, Bruno, Jr.; Hermann, Patrick C. 2019. "EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells." Cancers 11, no. 8: 1136.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.