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Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12

Institute of Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
Departments of Leukemia, MD Anderson Cancer Centre, Houston, TX 77030, USA
Hematology and Clinical Immunology Unit, Department of Medicine, Università di Padova, 35122 Padova, Italy
Hematology Unit, IRCCS Ca’ Granda Policlinico-Università degli Studi, 55031 Milano, Italy
Division of Hematology, Ospedale San Bortolo di Vicenza, 36100 Vicenza, Italy
Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy
Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, 10126 Torino, Italy
Hematology section, Department of Medical Sciences, Azienda Ospedaliero Universitaria Arcispedale S. Anna, 44124 Ferrara, Italy
Hematology Unit, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy
Hematology division, Policlinico Umberto I, Università Sapienza, 00161 Roma, Italy
Department of Hematology, Ospedale Niguarda, 20162 Milano, Italy
Biothecnology Research Unit, Azienda Ospedaliera di Cosenza, 87100 Cosenza, Italy
Department of Hematology-Oncology, Ospedale Pugliese-Ciacco, 88100 Catanzaro, Italy
Division of Hematology, Ospedale Belcolle, 01100 Viterbo, Italy
Hematology and Stem cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, 85028 Rionero in Vulture, Italy
Hematology and Stem Cell Transplantation Unit, Ospedale A. Businco, 09121 Cagliari, Italy
Department of Hematology, Azienda Ospedaliera Bianchi-Melacrino-Morelli, 89124 Reggio Calabria, Italy
Molecular Hematology, International Centre for Genetic Engineering and Biotechnology, 34149 Trieste, Italy
Institute of Hematology, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
Author to whom correspondence should be addressed.
Cancers 2019, 11(7), 896;
Received: 30 May 2019 / Revised: 16 June 2019 / Accepted: 18 June 2019 / Published: 26 June 2019
(This article belongs to the Special Issue Chronic Lymphocytic Leukemia)
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Chronic Lymphocytic Leukemia (CLL) patients with +12 have been reported to have specific clinical and biologic features. We performed an analysis of the association between demographic; clinical; laboratory; biologic features and outcome in CLL patients with +12 to identify parameters predictive of disease progression; time to treatment; and survival. The study included 487 treatment-naive CLL patients with +12 from 15 academic centers; diagnosed between January 2000 and July 2016; and 816 treatment-naïve patients with absence of Fluorescence In Situ Hybridization (FISH) abnormalities. A cohort of 250 patients with +12 CLL followed at a single US institution was used for external validation. In patients with +12; parameters associated with worse prognosis in the multivariate model were high Lactate DeHydrogenase (LDH) and β-2-microglobulin and unmutated immunoglobulin heavy-chain variable region gene (IGHV). CLL patients with +12 and high LDH levels showed a shorter Progression-Free-Survival (PFS) (30 months vs. 65 months; p < 0.001), Treatment-Free-Survival (TFS) (33 months vs. 69 months; p < 0.001), Overall Survival (OS) (131 months vs. 181 months; p < 0.001) and greater CLL-related mortality (29% vs. 11% at 10 years; p < 0.001) when compared with +12 CLL patients with normal LDH levels. The same differences were observed in the validation cohort. These data suggest that serum LDH levels can predict PFS; TFS; OS and CLL-specific survival in CLL patients with +12. View Full-Text
Keywords: CLL; trisomy 12; LDH; prognosis CLL; trisomy 12; LDH; prognosis

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Autore, F.; Strati, P.; Innocenti, I.; Corrente, F.; Trentin, L.; Cortelezzi, A.; Visco, C.; Coscia, M.; Cuneo, A.; Gozzetti, A.; Mauro, F.R.; Frustaci, A.M.; Gentile, M.; Morabito, F.; Molica, S.; Falcucci, P.; D’Arena, G.; Murru, R.; Vincelli, D.; Efremov, D.G.; Ferretti, A.; Rigolin, G.M.; Vitale, C.; Tisi, M.C.; Reda, G.; Visentin, A.; Sica, S.; Foà, R.; Ferrajoli, A.; Laurenti, L. Elevated Lactate Dehydrogenase Has Prognostic Relevance in Treatment-Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12. Cancers 2019, 11, 896.

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