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Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 2200 Copenhagen, Denmark
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Cancers 2019, 11(5), 729; https://doi.org/10.3390/cancers11050729
Received: 30 April 2019 / Revised: 21 May 2019 / Accepted: 22 May 2019 / Published: 26 May 2019
(This article belongs to the Special Issue The Role of Integrins in Cancer)
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Abstract

Members of the lysyl oxidase (LOX) family are secreted copper-dependent amine oxidases that catalyze the covalent crosslinking of collagens and elastin in the extracellular matrix (ECM), an essential process for the structural integrity of all tissues. LOX enzymes can also remodel the tumor microenvironment and have been implicated in all stages of tumor initiation and progression of many cancer types. Changes in the ECM can influence several cancer cell phenotypes. Integrin adhesion complexes (IACs) physically connect cells with their microenvironment. This review article summarizes the main findings on the role of LOX proteins in modulating the tumor microenvironment, with a particular focus on how ECM changes are integrated by IACs to modulate cells behavior. Finally, we discuss how the development of selective LOX inhibitors may lead to novel and effective therapies in cancer treatment. View Full-Text
Keywords: lysyl oxidase; integrins; adhesion complexes; extracellular matrix; cancer lysyl oxidase; integrins; adhesion complexes; extracellular matrix; cancer
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Amendola, P.G.; Reuten, R.; Erler, J.T. Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment. Cancers 2019, 11, 729.

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