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Oxaliplatin-Based Chemotherapy in Patients with Metastatic Colorectal Cancer Aged at Least 75 Years: A Post-Hoc Subgroup Analysis of Three Phase II Trials

U.O. Oncologia Medica, Azienda Ospedaliera S. Carlo, 85100 Potenza, Italy
Struttura Complessa di Oncologia Medica, Ospedale Garibaldi, 95122 Catania, Italy
Biostatistics and Data Management Unit, Medi Service S.r.l., 16149 Genova, Italy
Dipartimento di Oncologia Clinica, Ospedale San Bortolo, AULSS8, 36100 Vicenza, Italy
U.O. Oncologia Medica, Ospedale S. Giovanni di Dio, 92100 Agrigento, Italy
Struttura Complessa di Oncologia Clinica Sperimentale Addome, Dipartimento Assistenziale e di Ricerca dei Percorsi Oncologici del Distretto Addominale, Istituto Nazionale per lo Studio e la Cura dei Tumori “Fondazione Giovanni Pascale” — IRCCS, 80131 Napoli, Italy
U.O. Oncologia Medica, ASL NA3 Sud, 80035 Nola (NA), Italy
U.O. Oncologia Medica, Azienda Ospedaliero-Universitaria “Vittorio Emanuele”, 95124 Catania, Italy
U.O. Oncologia Medica, Istituto Oncologico del Mediterraneo, 95029 Viagrande (CT), Italy
U.O. Oncologia Medica, Azienda Ospedaliera Gravina, 95041 Caltagirone, Italy
Author to whom correspondence should be addressed.
Cancers 2019, 11(4), 578;
Received: 26 March 2019 / Revised: 17 April 2019 / Accepted: 21 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Colorectal Cancers)
Patients older than 75 years of age are usually excluded from metastatic colorectal cancer studies based on a combination chemotherapy containing oxaliplatin. Our group conducted three phase II trials in elderly patients in recent years. A post-hoc subgroup analysis of 67 patients aged at least 75 years was included in this study. Oxaliplatin was combined with capecitabine in two trials and with uracil-tegafur (UFT) plus folinic acid in the third trial. In one study, bevacizumab was also added to chemotherapy. The median age of patients was 77 years, and all had a good performance status (0 to 1). The observed overall response rate was 45%, comparable to younger patients (51%, p = 0.49). The estimated median progression-free survival (PFS) time and overall survival (OS) time were 8.7 and 19.3 months, respectively. These results did not significantly differ from those in younger patients (8.0 months for PFS (p = 0.58) and 19.7 months for OS (p = 0.94), respectively). The most common grade 3–4 adverse events included diarrhea (13%), fatigue (13%), peripheral neuropathy (10%), and neutropenia (7%). Moreover, the toxicity was never statistically different from that in younger patients. The efficacy of oxaliplatin-based combination was maintained in fit elderly patients ≥75 years. View Full-Text
Keywords: colorectal cancer; doublet chemotherapy; elderly patients; oxaliplatin colorectal cancer; doublet chemotherapy; elderly patients; oxaliplatin
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Rosati, G.; Cordio, S.; Reggiardo, G.; Aprile, G.; Butera, A.; Avallone, A.; Tucci, A.; Novello, G.; Blanco, G.; Caputo, G.; Bilancia, D.; Bordonaro, R. Oxaliplatin-Based Chemotherapy in Patients with Metastatic Colorectal Cancer Aged at Least 75 Years: A Post-Hoc Subgroup Analysis of Three Phase II Trials. Cancers 2019, 11, 578.

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