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The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma

Department of Neurosurgery, University Medicine Greifswald, 17475 Greifswald, Germany
Department of Pharmacology, Center of Drug Absorption and Transport, University Medicine Greifswald, 17487 Greifswald, Germany
Department of Transfusion Medicine, University Medicine Greifswald, 17475 Greifswald, Germany
Author to whom correspondence should be addressed.
Cancers 2019, 11(4), 569;
Received: 27 March 2019 / Revised: 11 April 2019 / Accepted: 18 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Glioblastoma: State of the Art and Future Perspectives)
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The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. This review summarizes the current understanding of the platelet–immune cell communication and its potential role in glioma resistance and progression. Particularly, we focus on platelet-derived proinflammatory modulators, such as sphingosine-1-phosphate (S1P). The multifaceted interaction with immune cells puts the platelet into an interesting perspective regarding the recent advances in immunotherapeutic approaches in malignant glioma. View Full-Text
Keywords: glioblastoma multiforme; platelet; immune cell interaction; sphingosine-1-phosphate glioblastoma multiforme; platelet; immune cell interaction; sphingosine-1-phosphate

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Marx, S.; Xiao, Y.; Baschin, M.; Splittstöhser, M.; Altmann, R.; Moritz, E.; Jedlitschky, G.; Bien-Möller, S.; Schroeder, H.W.; Rauch, B.H. The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma. Cancers 2019, 11, 569.

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