Next Article in Journal
ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion
Next Article in Special Issue
Gastric Microbiota in Helicobacter pylori-Negative and -Positive Gastritis Among High Incidence of Gastric Cancer Area
Previous Article in Journal
Proteomic Analysis Implicates Vimentin in Glioblastoma Cell Migration
Previous Article in Special Issue
Mutated Rnf43 Aggravates Helicobacter Pylori-Induced Gastric Pathology
Article Menu

Export Article

Open AccessArticle
Cancers 2019, 11(4), 467; https://doi.org/10.3390/cancers11040467

Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process

1
Department of Epidemiology, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
2
Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
3
Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
*
Author to whom correspondence should be addressed.
Received: 4 February 2019 / Revised: 21 March 2019 / Accepted: 27 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Helicobacter pylori Associated Cancer)
  |  
PDF [264 KB, uploaded 18 April 2019]
  |  

Abstract

Gastric cancer is the third leading cause of cancer mortality worldwide. Studies investigating the effect of salt on gastric cancer have mainly used self-reported measures, which are not as accurate as sodium/creatinine ratios because individuals may not know the amount of salt in their food. Using data from a prospective cohort study, we investigated the effect of salt intake on progression to gastric precancerous lesions. Salt intake was estimated by urinary sodium/creatinine ratios, self-reported frequencies of adding salt to food, and total added table salt. We repeated the analyses among groups with and without Helicobacter pylori infection. We did not observe a positive association between salt intake, measured by urinary sodium/creatinine ratio, and overall progression in the gastric precancerous process (adjusted risk ratio (RR): 0.94; 95% confidence interval (CI) 0.76–1.15). We did observe an association between salt intake and increased risk for progression to dysplasia or gastric cancer overall (RR: 1.32; 95% CI: 0.96–1.81), especially among those who continued to have H. pylori infection at the five-month follow-up (adjusted RR: 1.53; 95% CI: 1.12–2.09), and among those who had persistent H. pylori infection over 12 years (adjusted RR: 1.49; 95% CI: 1.09–2.05). Salt intake may increase the risk of gastric dysplasia or gastric cancer in individuals with H. pylori infection. View Full-Text
Keywords: salt intake; gastric cancer; atrophic gastritis; intestinal metaplasia; dysplasia salt intake; gastric cancer; atrophic gastritis; intestinal metaplasia; dysplasia
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Thapa, S.; Fischbach, L.A.; Delongchamp, R.; Faramawi, M.F.; Orloff, M. Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process. Cancers 2019, 11, 467.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top