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Correction: Hiroshi Sugano et al. Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells. Cancers 2018, 10, 386

Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer

Department of Pharmaceutical Sciences, University of Tennessee Health Science Centre, Memphis, TN 38163, USA
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India
Department South Dakota State University, Brookings, SD 57007, USA
Authors to whom correspondence should be addressed.
Cancers 2019, 11(3), 364;
Received: 30 October 2018 / Revised: 25 February 2019 / Accepted: 8 March 2019 / Published: 14 March 2019
(This article belongs to the Collection Drug Resistance and Novel Therapies in Cancers)
Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc D) effectively inhibits glucose uptake and lactate production in metastatic PrCa cells via modulating glucose metabolism. This metabolic shift by Cuc D was correlated with decreased expression of GLUT1 by its direct binding as suggested by its proficient molecular docking (binding energy −8.5 kcal/mol). Cuc D treatment also altered the expression of key oncogenic proteins and miR-132 that are known to be involved in glucose metabolism. Cuc D (0.1 to 1 µM) treatment inhibited tumorigenic and metastatic potential of human PrCa cells via inducing apoptosis and cell cycle arrest in G2/M phase. Cuc D treatment also showed inhibition of tumor growth in PrCa xenograft mouse model with concomitant decrease in the expression of GLUT1, PCNA and restoration of miR-132. These results suggest that Cuc D is a novel modulator of glucose metabolism and could be a promising therapeutic modality for the attenuation of PrCa metastasis. View Full-Text
Keywords: cucurbitacin D; PrCa; miRNAs and glucose metabolism cucurbitacin D; PrCa; miRNAs and glucose metabolism
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MDPI and ACS Style

Sikander, M.; Malik, S.; Chauhan, N.; Khan, P.; Kumari, S.; Kashyap, V.K.; Khan, S.; Ganju, A.; Halaweish, F.T.; Yallapu, M.M.; Jaggi, M.; Chauhan, S.C. Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. Cancers 2019, 11, 364.

AMA Style

Sikander M, Malik S, Chauhan N, Khan P, Kumari S, Kashyap VK, Khan S, Ganju A, Halaweish FT, Yallapu MM, Jaggi M, Chauhan SC. Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer. Cancers. 2019; 11(3):364.

Chicago/Turabian Style

Sikander, Mohammed, Shabnam Malik, Neeraj Chauhan, Parvez Khan, Sonam Kumari, Vivek Kumar Kashyap, Sheema Khan, Aditya Ganju, Fathi T. Halaweish, Murali M. Yallapu, Meena Jaggi, and Subhash C. Chauhan. 2019. "Cucurbitacin D Reprograms Glucose Metabolic Network in Prostate Cancer" Cancers 11, no. 3: 364.

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