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Cancers 2019, 11(3), 289; https://doi.org/10.3390/cancers11030289

Open Partial Horizontal Laryngectomies for T3–T4 Laryngeal Cancer: Prognostic Impact of Anterior vs. Posterior Laryngeal Compartmentalization

1
Department of Otorhinolaryngology—Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy
2
Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, 20133 Milan, Italy
3
Department of Otorhinolaryngology, Head and Neck Surgery, University of Genoa—IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 22 January 2019 / Revised: 23 February 2019 / Accepted: 24 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Emerging Concepts in Treatment of Laryngeal Cancer)
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Abstract

Open partial horizontal laryngectomies (OPHLs) are well-established and oncologically safe procedures for intermediate–advanced laryngeal cancers (LC). T–N categories are well-known prognosticators: herein we tested if “anterior” vs. “posterior” tumor location (as defined in respect to the paraglottic space divided according to a plane passing through the arytenoid vocal process, perpendicular to the ipsilateral thyroid lamina) may represent an additional prognostic factor. We analyzed a retrospective cohort of 85 T3–4a glottic LCs, treated by Type II or III OPHL (according to the European Laryngological Society classification) from 2005 to 2017 at two academic institutions. Five-year overall survival (OS), disease-specific survivals (DSS), and recurrence-free survivals (RFS) were compared according to tumor location and pT category. Anterior and posterior tumors were 43.5% and 56.5%, respectively, 78.8% of lesions were T3 and 21.2% were T4a. Five-year OS, DSS, and RFS for T3 were 74.1%, 80.5%, and 63.4%, respectively, and for T4a 71.8%, 71.8%, and 43%, respectively (p not significant). In relation to tumor location, the survival outcomes were 91%, 94.1%, and 72.6%, respectively, for anterior tumors, and 60.3%, 66.3%, and 49.1%, respectively, for posterior lesions (statistically significant differences). These data provide evidence that laryngeal compartmentalization is a valid prognosticator, even more powerful than the pT category. View Full-Text
Keywords: laryngeal cancer; open partial horizontal laryngectomy; conservative surgery; paraglottic space; prognosis laryngeal cancer; open partial horizontal laryngectomy; conservative surgery; paraglottic space; prognosis
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Del Bon, F.; Piazza, C.; Lancini, D.; Paderno, A.; Bosio, P.; Taboni, S.; Morello, R.; Montalto, N.; Missale, F.; Incandela, F.; Marchi, F.; Filauro, M.; Deganello, A.; Peretti, G.; Nicolai, P. Open Partial Horizontal Laryngectomies for T3–T4 Laryngeal Cancer: Prognostic Impact of Anterior vs. Posterior Laryngeal Compartmentalization. Cancers 2019, 11, 289.

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